Demir, EmekCary, M. P.Paley, S.Fukuda, K.Lemer, C.Vastrik, I.Wu, G.D'Eustachio, P.Schaefer, C.Luciano, J.Schacherer, F.Martinez-Flores, I.Hu, Z.Jimenez-Jacinto, V.Joshi-Tope, G.Kandasamy, K.Lopez-Fuentes, A. C.Mi, H.Pichler, E.Rodchenkov, I.Splendiani, A.Tkachev, S.Zucker, J.Gopinath, G.Rajasimha, H.Ramakrishnan, R.Shah, I.Syed, M.Anwar, N.Babur, ÖzgünBlinov, M.Brauner, E.Corwin, D.Donaldson, S.Gibbons, F.Goldberg, R.Hornbeck, P.Luna, A.Murray-Rust, P.Neumann, E.Reubenacker, O.Samwald, M.Iersel, Martijn vanWimalaratne, S.Allen, K.Braun, B.Whirl-Carrillo, M.Cheung, Kei-HoiDahlquist, K.Finney, A.Gillespie, M.Glass, E.Gong, L.Haw, R.Honig, M.Hubaut, O.Kane, D.Krupa, S.Kutmon, M.Leonard, J.Marks, D.Merberg, D.Petri, V.Pico, A.Ravenscroft, D.Ren, L.Shah, N.Sunshine, M.Tang R.Whaley, R.Letovksy, S.Buetow, K. H.Rzhetsky, A.Schachter, V.Sobral, B. S.Doğrusöz, UğurMcWeeney, S.Aladjem, M.Birney, E.Collado-Vides, J.Goto, S.Hucka, M.Novère, Nicolas LeMaltsev, N.Pandey, A.Thomas, P.Wingender, E.Karp, P. D.Sander, C.Bader, G. D.2018-04-122018-04-122010-091087-0156http://hdl.handle.net/11693/38163Biological Pathway Exchange (BioPAX) is a standard language to represent biological pathways at the molecular and cellular level and to facilitate the exchange of pathway data. The rapid growth of the volume of pathway data has spurred the development of databases and computational tools to aid interpretation; however, use of these data is hampered by the current fragmentation of pathway information across many databases with incompatible formats. BioPAX, which was created through a community process, solves this problem by making pathway data substantially easier to collect, index, interpret and share. BioPAX can represent metabolic and signaling pathways, molecular and genetic interactions and gene regulation networks. Using BioPAX, millions of interactions, organized into thousands of pathways, from many organisms are available from a growing number of databases. This large amount of pathway data in a computable form will support visualization, analysis and biological discovery. © 2010 Nature America, Inc. All rights reserved.EnglishBiological discoveriesBiological pathwaysCellular levelsCommunity standardsComputational toolsData sharingGene regulation networkGenetic interactionRapid growthSignaling pathwaysDatabase systemsVisualizationData visualizationMessenger RNAProtein kinase BBiological pathway exchangeCopy number variationDatabaseEnzyme substrateFragmentation reactionMetabolismMolecular biologyMolecular dynamicsMolecular evolutionMolecular interactionPriority journalPromoter regionProtein DNA interactionProtein expressionProtein modificationProtein protein interactionProtein structureReviewSemanticsSingle nucleotide polymorphismStructure analysisComputational biologyDatabases as topicInformation disseminationMetabolic networks and pathwaysProgramming languagesSignal transductionSoftwareArticle10.1038/nbt.1666