Gurdal, E. E.Durmaz, I.Cetin Atalay, R.Yarim, M.2016-02-082016-02-0820141475-6366http://hdl.handle.net/11693/26682Synthesis and cytotoxic activities of 32 benzhydrylpiperazine derivatives with carboxamide and thioamide moieties were reported. In vitro cytotoxic activities of compounds were screened against hepatocellular (HUH-7), breast (MCF-7) and colorectal (HCT-116) cancer cell lines by sulphorhodamine B assay. In general, 4-chlorobenzhydrylpiperazine derivatives were more cytotoxic than other compounds. In addition, thioamide derivatives (6a-g) have higher growth inhibition than their carboxamide analogs. © 2014 Informa UK Ltd. All rights reserved.EnglishBenzhydrylpiperazineCytotoxicityIsocyanateIsothiocyanateSulphorhodamine BArticle10.3109/14756366.2013.765416