NishaSharma, Mr. C.Kumar, R.Kumar, Y.2019-02-212019-02-212018http://hdl.handle.net/11693/50073We report herein an efficient, straightforward and ligand free synthesis of aminopyridyl carboxylates, an important building block used in pharmaceuticals and agrochemicals. The C(sp2)-N bond formation utilize a readily available Cu-catalyst, NaN3 as the amino source in ethanol, and the corresponding ortho-functionalized aromatic amines were synthesized in good to excellent yields. This ligand free one-pot domino methodology proceeds through Ullmann-type coupling of halopyridyl carboxylates with sodium azide followed by reduction with ethanol. These functionalized aminopyridyl carboxylates provides an easy access to biologically potent pyrido[2, 3-d]pyrimidin-4(1H)-one hybrids.EnglishAminationCopper-catalyzed reactionNicotinamideNicotinic acidUllmann couplingArticle10.1002/slct.2018009072365-6549