Çikla-Süzgün P.Kaushik-Basu, N.Basu, A.Arora P.Talele, T.T.Durmaz I.Çetin-Atalay, R.Küçükgüzel, S.G.2016-02-082016-02-08201514756366http://hdl.handle.net/11693/21070Arachidonic acid is an unsaturated fatty acid liberated from phospholipids of cell membranes. NSAIDs are known as targets of cyclooxygenase enzyme (COX-1, COX-2 and COX-3) in arachidonic acid metabolism. This mechanism of COX-2 in carcinogenesis causes cancer. In addition, COX-2 plays a role in the early stages of hepatocarcinogenesis. Hepatitis C virus (HCV) infection is cause of liver cirrhosis and hepatocellular carcinoma (HCC). The aim of our study was to improve effective agents against HCV. A novel series of new etodolac 1,2,4-triazoles derivatives (4a-h) have been synthesized and investigated for their activity against HCV NS5B polymerase. Compound 4a was found to be the most active with IC<inf>50</inf> value of 14.8 M. In accordance with these results, compound 4a was screened for anti-cancer activity on liver cancer cell lines (Huh7, Mahlavu, HepG2, FOCUS). Compound 4a showed anti-cancer activity against Huh7 human hepatoma cell line with IC<inf>50</inf> value of 4.29 M. Therefore, compound 4a could be considered as a new anti-cancer and anti-HCV lead compound. © 2015 Informa UK Ltd.English1,2,4-Triazole-3-thioneetodolacHCV NS5B polymerasehepatocellular carcinoma5 [(1,8 diethyl 1,3,4,9 tetrahydropyrano[3,4 b]indole 1 yl) methyl] 4 benzyl 2,4 dihydro 3h 1,2,4 triazole 3 thione5 [(1,8 diethyl 1,3,4,9 tetrahydropyrano[3,4 b]indole 1 yl) methyl] 4 methyl 2,4 dihydro 3h 1,2,4 triazole 3 thioneantivirus agentcyclooxygenase 1cyclooxygenase 2etodolacnonstructural protein 5Btriazole derivativeunclassified drugantineoplastic activityantiviral activityArticledrug synthesisgrowth inhibitionHepatitis C virushepatocellular carcinoma cell linehumanhuman cellIC50liver cancer cell linepriority journalvirus infectionArticle10.3109/14756366.2014.971780