Akyerli, C. B.Beksac, M.Holko, M.Frevel, M.Dalva, K.Özbek, U.Soydan, E.Özcan, M.Özet, G.İlhan, O.Gürman, G.Akan, H.Williams, B. R. G.Özçelik, T.2016-02-082016-02-0820050145-2126http://hdl.handle.net/11693/24093We investigated the peripheral blood gene expression profile of interferon induced transmembrane protein 1 (IFITM1) in sixty chronic myeloid leukemia (CML) patients classified according to new prognostic score (NPS). IFITM1 is a component of a multimeric complex involved in the trunsduction of antiproliferative and cell adhesion signals. Expression level of IFITM1 was found significantly different between the high- and low-risk groups (P = 9.7976 × 10-11) by real-time reverse transcription polymerase chain reaction (RT-PCR). Higher IFITM1 expression correlated with improved survival (P = 0.01). These results indicate that IFITM1 expression profiling could be used for molecular classification of CML, which may also predict survival.EnglishChronic myeloid leukemiaGene expressionIFITM1RT-PCRInterferon induced transmembrane protein 1Membrane proteinUnclassified drugArticleBloodCell adhesionCell proliferationChronic myeloid leukemiaControlled studyCorrelation analysisDisease classificationFemaleGene expressionHigh risk populationHumanMajor clinical studyMalePredictionPriority journalPrognosisReal time polymerase chain reactionSignal transductionSurvivalAdultAgedHumansLeukemia, Myeloid, ChronicMaleMembrane ProteinsMiddle AgedPrognosisReverse Transcriptase Polymerase Chain ReactionSurvival AnalysisTumor Markers, BiologicalArticle10.1016/j.leukres.2004.07.007