# _embedded.searchResult._embedded.objects[]._embedded.indexableObject.name
Characterization of chemosensitivity profiles of breast cancer cell lınes, with and without stem cell like features = Kök-hücre özelliği olan ve olmayan meme kanseri hücre hatlarının ilaç hassasiyet profillerinin tanımlanması

# _embedded.searchResult._embedded.objects[]._embedded.indexableObject.metadata.dc.description.abstract[].value
Breast cancer is the second most common cause of death worldwide from cancer due to
complications with its diagnosis and resistance to therapy. Recent studies have shown that
breast tumors when compared with other solid tumors also contain a subpopulation termed as
cancer stem cells (CSCs). CSCs are hard to kill due to their therapy resistant capacities. These
unharmed cells then result into relapse of tumor after treatment. Some established breast
cancer cell lines also behave in similar fashion to CSCs in overall manner thus termed as CSC
like cell lines. This study primarily focuses on characterizing CSC like cell lines from non CSC
like cell lines based upon their gene expression and prediction of drugs which can target these
groups separately. In this study two databases, Cancer Cell Line Encyclopedia (CCLE) and
Cancer Genome Project (CGP), were used which contain gene expression data and drugs
cytotoxicity data for most of the established cancer cell lines. Breast cancer cell lines gene
expression data was used to predict two gene lists which can separate breast cancer cell lines
into CSC like and non CSC like cell lines by in silico analysis. These gene lists were named as
Patentable and Non Patentable. Additionally four drugs were predicted which can target CSC
like group (Midostaurin and Elesclomol) and non CSC like group (Panobinostat and Lapatinib)
separately. Later these findings were validated in vitro. Non Patentable gene list could not be
validated due to low concordance with microarray data. On the other hand, Patentable gene list
was validated and was found concordant with microarray data. Out of four selected drugs,
Panobinostat and Lapatinib showed increased toxicity to non CSC like cell lines while only
Midostaurin showed toxicity to CSC like cell lines. To investigate further that cell lines were
grown in 3D cell culture conditions, to increase their stem cell like properties (stemness). But
only one cell line MDA-MB-157 which was found as CSC like, showed expected behavior.
Additionally this cell line increased resistance to Lapatinib and Panobinostat and became more
sensitive to Midostaurin. Correlation analysis showed some genes as potential biomarkers for
selected drugs. In conclusion, in this study various genes are proposed to differentiate CSC like cell lines from non CSC like cell lines. And Midostaurin can be potential drug to treat CSC like
cells while Lapatinib and Panobinostat showed increased activity against non CSC like cell
lines.

# _embedded.searchResult._embedded.objects[]._embedded.indexableObject.metadata.dc.format.extent[].value
xvi, 107 leaves, charts, plates, illustrations

# _embedded.searchResult._embedded.objects[]._embedded.indexableObject.metadata.dc.title[].value
Characterization of chemosensitivity profiles of breast cancer cell lınes, with and without stem cell like features = Kök-hücre özelliği olan ve olmayan meme kanseri hücre hatlarının ilaç hassasiyet profillerinin tanımlanması

# _embedded.searchResult._embedded.objects[]._embedded.indexableObject.name
Inorganic / polymeric assemblies as catalysts for water splitting

# _embedded.searchResult._embedded.objects[]._embedded.indexableObject.metadata.dc.description.abstract[].value
Splitting water with sunlight is an attractive and promising research topic over
the last two decades since it produces a non-carbon-based resource, hydrogen,
which is a suitable energy carrier due to its high energy output and for being
environmentally friendly. A great deal of research in this  eld has been centered
on the development of e cient water oxidation and reduction catalysts.
The  rst part of the thesis focuses on a novel photosensitizer-water oxidation
catalyst (PS-WOC) dyad. A Ru metal coordinated pyridine-based ligand
and a cobalt-iron pentacyanoferrate have been used as the photosensitizer and
water oxidation catalyst, respectively. In this assembly, poly(4-vinylpyridine)
serves as the bridging group between two units mainly to enhance the performance
and stability of the system compared to its analogous intermolecular system.
A 5-fold improvement on the catalytic activity has been achieved with a
turnover frequency (TOF) of 5:6   10-4 s-1 under 1 hour light illumination and
a turnover number (TON) of 11 in a 6-hour catalytic study. Evolved oxygen was
quanti ed with gas chromatography. Structural characterization was carried out
by Fourier Transform Infrared Spectroscopy (FTIR), Ultraviolet-Visible Spectroscopy
(UV-Vis), X-Ray Photoelectron Spectroscopy (XPS), X-Ray Powder
Di raction (XRD), Scanning Electron Microscopy (SEM), and Energy-dispersive
X-Ray Spectroscopy (EDX) techniques. Comparative XPS and FTIR studies
were performed on pristine and post-catalytic samples to con rm the stability of
the dyad.
In the second part of the study, a facile synthetic pathway using poly(4-
vinylpyridine) as a polypyridyl platform has been reported for the formation of
a cobalt-based metallopolymer. Electrochemical studies indicate that the metallopolymer
acts as an e cient H2 evolution catalyst similar to cobalt-polypyridyl
complexes. Furthermore, metallopolymer can be transformed to cobalt particles
when a cathodic potential is applied in the presence of an acid. It has been found
that these cobalt particles also serve as e cient hydrogen evolution catalysts. Approximately
80  µmoles of H2 gas can be collected during 2 h of electrolysis at -1.5
V (vs. Fc+/0) in the presence of 60 mM of acetic acid. A comprehensive study of
the electrochemical and electrocatalytic behavior of cobalt-poly(4-vinylpyridine)
was discussed in detail.

# _embedded.searchResult._embedded.objects[]._embedded.indexableObject.metadata.dc.format.extent[].value
xix, 72 leaves : illustrations, charts (some color) ; 30 cm.

# _embedded.searchResult._embedded.objects[]._embedded.indexableObject.metadata.dc.title[].value
Inorganic / polymeric assemblies as catalysts for water splitting

# _embedded.searchResult._embedded.objects[]._embedded.indexableObject.metadata.dc.title.alternative[].value
Suyun ayrışma reaksiyonu için inorganik / polimerik yapılı katalizörler

# _embedded.searchResult._embedded.objects[]._embedded.indexableObject.name
Evaluation of design studios in terms of environmental comfort conditions

# _embedded.searchResult._embedded.objects[]._embedded.indexableObject.metadata.dc.description.abstract[].value
Buildings create environments for people to live and work in, and they aim at providing occupant satisfaction. In order to create interior environments which are completely suitable for the activities they involve, some requirements have to be met. These requirements relate to the environmental comfort conditions, the components of which are thermal, visual and acoustical comfort. The important point is that the effects of heat, light and sound are not isolated elements of building design; they are interrelated. In this study, which is a field study, environmental comfort conditions in the design studio are analyzed. Design studios are chosen since there is a living process in these environments where many different functions take place simultaneously. For this purpose, the design studios of the Department of Interior Architecture and Environmental Design, Faculty of Art, Design and Architecture at Bilkent University in Ankara, Turkey are analyzed. The analysis consists of the physical measurements of the environmental comfort parameters, and the subjective responses of the occupants which are evaluated with questionnaires. In order to make an evaluation, the obtained values for physical measurements are compared with the ones compiled from the relevant standards, and the questionnaire responses are analyzed. At the end of the study, recommendations for the amelioration of the measured studios are made.

# _embedded.searchResult._embedded.objects[]._embedded.indexableObject.metadata.dc.title[].value
Evaluation of design studios in terms of environmental comfort conditions

# _embedded.searchResult._embedded.objects[]._embedded.indexableObject.metadata.thesis.degree.discipline[].value
Interior Architecture and Environmental Design

# _embedded.searchResult._embedded.objects[]._embedded.indexableObject.name
"Unutmaya karşı çıkmak, otoriteye karşı çıkmaktır" : Süreyya Evren

# _embedded.searchResult._embedded.objects[]._embedded.indexableObject.metadata.dc.description[].value
Varlık Dergisi -- Temmuz 1994 -- pages 9.

# _embedded.searchResult._embedded.objects[]._embedded.indexableObject.metadata.dc.title[].value
"Unutmaya karşı çıkmak, otoriteye karşı çıkmaktır" : Süreyya Evren

# _embedded.searchResult._embedded.objects[]._embedded.indexableObject.name
Polymorphisms of Glutathione S- transferase genes (GSTM1, GSTP1, and GSTT1) and breast cancer susceptibility in the Turkish population

# _embedded.searchResult._embedded.objects[]._embedded.indexableObject.metadata.dc.description.abstract[].value
The potential association between the Glutathione S- transferase genes
GSTM1, GSTT1, GSTP1 and breast cancer susceptibility was investigated in a case
control study of 264 female patients and 233 age-matched controls in the Turkish
population. The combined GSTP1 105 Ile/Val or Val/Val genotypes was
significantly associated with breast cancer risk in all women (odds ratio OR=1.64,
95% confidence interval CI=1.09-2.47 and in premenopausal women is OR= 2.01,
95% CI=1.06-3.83). Neither GSTM1 nor GSTT1 was found to be associated with
breast cancer. Distribution of GSTP1 genotypes was stratified according to body
mass index (BMI), age, age at menarche, age at full-term pregnancy, number of fullterm
pregnancies, and family history of breast cancer. The association of the
combined GSTP1 105 Ile/Val or Val/Val genotypes with breast cancer risk was
further exacerbated in women with high BMI (OR=2.12, 95% CI=1.35-3.62), but not
with a low BMI (OR=0.78, 95% CI=0.45-1.34). These findings support the role for
the combined GSTP1 105 Ile/Val or Val/Val genotypes in the development of breast
cancer, particularly with a high BMI.

# _embedded.searchResult._embedded.objects[]._embedded.indexableObject.metadata.dc.format.extent[].value
xi, 98 leaves, illustrations, tables, graphs, 30 cm

# _embedded.searchResult._embedded.objects[]._embedded.indexableObject.metadata.dc.title[].value
Polymorphisms of Glutathione S- transferase genes (GSTM1, GSTP1, and GSTT1) and breast cancer susceptibility in the Turkish population

# _embedded.searchResult._embedded.objects[]._embedded.indexableObject.name
"Denize açılan kapı" çevresinde Rasim Özdenören'le bir konuşma

# _embedded.searchResult._embedded.objects[]._embedded.indexableObject.metadata.dc.description[].value
Mavera Aylık Edebiyat Dergisi -- Şubat 1985 -- pages 51-55.

# _embedded.searchResult._embedded.objects[]._embedded.indexableObject.metadata.dc.title[].value
"Denize açılan kapı" çevresinde Rasim Özdenören'le bir konuşma

# _embedded.searchResult._embedded.objects[]._embedded.indexableObject.name
Farklı bir kent, farklı yaşam biçimleri ve farklı kadınlar... : Ayla Kutlu / 1991 Sait Faik hikaye armağanı

# _embedded.searchResult._embedded.objects[]._embedded.indexableObject.metadata.dc.description[].value
Milliyet Sanat Dergisi. -- Mayıs 1991, p. 24-26.

# _embedded.searchResult._embedded.objects[]._embedded.indexableObject.metadata.dc.title[].value
Farklı bir kent, farklı yaşam biçimleri ve farklı kadınlar... : Ayla Kutlu / 1991 Sait Faik hikaye armağanı

# _embedded.searchResult._embedded.objects[]._embedded.indexableObject.name
Electronic structure analysis of a new quinoid conjugated polymer

# _embedded.searchResult._embedded.objects[]._embedded.indexableObject.metadata.dc.description.abstract[].value
The low lying unoccupied orbitals of oligomers of 4-dicyanomethylene-4H-cyclopenta[2,1-b:3,4-b'] dithiophene (CDM) are not delocalized over the whole molecule. Is such electron localization in the conduction band of poly-CDM responsible for its low n-type conductivity? Are polymers of the tricyclic thioketone (TCT) with more delocalized unoccupied orbitals a better alternative for stable n-dopable conducting polymers? Monomer through tetramer of TCT have been optimized with density functional theory. IP, EA, energy gap, and band width of the corresponding polymer were obtained by extrapolation. Comparison with data for oligomers of 4-dicyanomethylene-4H-cyclopenta[2,1-b:3,4-b'] dithiophene and of thiophene indicates that the novel polymer would have a small band gap and would fulfil the conditions for n-dopability and high mobility of n-type carriers. © Springer-Verlag 2000.

# _embedded.searchResult._embedded.objects[]._embedded.indexableObject.metadata.dc.title[].value
Electronic structure analysis of a new quinoid conjugated polymer

# _embedded.searchResult._embedded.objects[]._embedded.indexableObject.name
Hasan Âli Yücel fotoğraf koleksiyonu : HAYC50-747

# _embedded.searchResult._embedded.objects[]._embedded.indexableObject.metadata.dc.coverage[].value
Finding aid available in the Bilkent University Library Hasan Âli Yücel Collection

# _embedded.searchResult._embedded.objects[]._embedded.indexableObject.metadata.dc.description[].value
Digital version is available only through the Bilkent University Intitutional Repository.

# _embedded.searchResult._embedded.objects[]._embedded.indexableObject.metadata.dc.description[].value
İhsan Doğramacı Bilkent University, Main Campus Library Building, Hasan Âli Yücel Collection  Ankara  Turkey  06800  0-312-266-4472  0-312-266-4391  library@bilkent.edu.tr

# _embedded.searchResult._embedded.objects[]._embedded.indexableObject.metadata.dc.description[].value
Organized alphanumeric file classification according to subject.

# _embedded.searchResult._embedded.objects[]._embedded.indexableObject.metadata.dc.description[].value
Physical collection is stored in closed stack; digital version is available only through the Bilkent University Intitutional Repository.

# _embedded.searchResult._embedded.objects[]._embedded.indexableObject.metadata.dc.publisher[].value
Central Campus Library. Bilkent University Library.

# _embedded.searchResult._embedded.objects[]._embedded.indexableObject.metadata.dc.rights.general[].value
Collection is open for research use. Not available for commercial use, sale, or reproduction.

# _embedded.searchResult._embedded.objects[]._embedded.indexableObject.metadata.dc.title[].value
Hasan Âli Yücel fotoğraf koleksiyonu : HAYC50-747

# _embedded.searchResult._embedded.objects[]._embedded.indexableObject.name
Revisiting the complex architecture of ALS in Turkey: expanding genotypes, shared phenotypes, molecular networks, and a public variant database

# _embedded.searchResult._embedded.objects[]._embedded.indexableObject.metadata.dc.description.abstract[].value
The last decade has proven that amyotrophic lateral sclerosis (ALS) is clinically and genetically heterogeneous, and that the genetic component in sporadic cases might be stronger than expected. This study investigates 1,200 patients to revisit ALS in the ethnically heterogeneous yet inbred Turkish population. Familial ALS (fALS) accounts for 20% of our cases. The rates of consanguinity are 30% in fALS and 23% in sporadic ALS (sALS). Major ALS genes explained the disease cause in only 35% of fALS, as compared with ~70% in Europe and North America. Whole exome sequencing resulted in a discovery rate of 42% (53/127). Whole genome analyses in 623 sALS cases and 142 population controls, sequenced within Project MinE, revealed well‐established fALS gene variants, solidifying the concept of incomplete penetrance in ALS. Genome‐wide association studies (GWAS) with whole genome sequencing data did not indicate a new risk locus. Coupling GWAS with a coexpression network of disease‐associated candidates, points to a significant enrichment for cell cycle‐ and division‐related genes. Within this network, literature text‐mining highlights DECR1, ATL1, HDAC2, GEMIN4, and HNRNPA3 as important genes. Finally, information on ALS‐related gene variants in the Turkish cohort sequenced within Project MinE was compiled in the GeNDAL variant browser (www.gendal.org).

# _embedded.searchResult._embedded.objects[]._embedded.indexableObject.metadata.dc.description.sponsorship[].value
TÜBITAK, Grant/Award Number: 109S075;Bogaziçi University Research Funds,Grant/Award Number: 15B01P1; Suna andİnan Kıraç Foundation, Grant/Award Number:2005–2020

# _embedded.searchResult._embedded.objects[]._embedded.indexableObject.metadata.dc.title[].value
Revisiting the complex architecture of ALS in Turkey: expanding genotypes, shared phenotypes, molecular networks, and a public variant database

# _embedded.searchResult._embedded.objects[]._embedded.indexableObject.metadata.dc.description[].value
Kavram-Karmaşa -- Mart-Nisan 1997 -- pages 57-62.

# _embedded.searchResult._embedded.objects[]._embedded.indexableObject.name
Solution of electromagnetic scattering problems involving curved surfaces

# _embedded.searchResult._embedded.objects[]._embedded.indexableObject.metadata.dc.description.abstract[].value
The method of moments (MoM) is an efficient technique for the solution of
electromagnetic scattering problems. Problems encountered in real-life applications
are often three dimensional and involve electrically large scatterers with
complicated geometries. When the MoM is employed for the solution of these
problems, the size of the resulting matrix equation is usually large. It is possible
to reduce the size of the system of equations by improving the geometry
modeling technique in the MoM algorithm. Another way of improving the efficiency
of the MoM is the fast multipole method (FMM). The FMM reduces the
computational complexity of the convensional MoM. The FMM has also lower
memory-requirement complexity than the MoM. This facilitates the solution
of larger problems on a given hardware in a shorter period of time. The combination
of the FMM and the higher-order geometry modeling techniques is
proposed for the efficient solution of large electromagnetic scattering problems
involving three-dimensional, arbitrarily shaped, conducting suriace scatterers.

# _embedded.searchResult._embedded.objects[]._embedded.indexableObject.metadata.dc.title[].value
Solution of electromagnetic scattering problems involving curved surfaces

# _embedded.searchResult._embedded.objects[]._embedded.indexableObject.name
Non-equilibrium steady state phase transitions of various statistical models

# _embedded.searchResult._embedded.objects[]._embedded.indexableObject.metadata.dc.description[].value
Includes bibliographical references leaves  79-88.

# _embedded.searchResult._embedded.objects[]._embedded.indexableObject.metadata.dc.description.abstract[].value
Non-equilibrium phase transitions of a number of systems are investigated by
several methods. These systems are in contact with thermal baths with different
temperatures and taken to be driven to the non-equilibrium limits by spin
exchange (Kawasaki) dynamics.
First of all, the criticality of the two-finite temperature spin-1/2 Ising model
with a conserved order parameter on a square lattice is studied through a
real space renormalization group transformation. The dynamics of the nonequilibrium
system are characterized by means of different temperatures (Tx and
Ty), and also different time-scale constants, (αx and αy) for spin exchanges in the
x and y directions. Based on the RG flows, the critical surface of the system is
obtained as a function of these exchange parameters. This is the first study in
which the full critical surface displaying various universality classes of this system
is reported.
Secondly, steady state phase transitions of the eight-vertex model, formulated
by two interlaced two-dimensional Ising models on square lattices, are studied
through four independent Monte Carlo simulations, each with 60 × 106 Monte
Carlo steps on N × N lattices with N = 32, 40, 80, 100. To obtain an isotropic
system, the spin exchanges are considered to occur within the sublattices. We
observe non-universal behavior for non-equilibrium transitions around the equilibrium
transitions, and Ising like behavior when one of the bath temperature
becomes very large.

# _embedded.searchResult._embedded.objects[]._embedded.indexableObject.metadata.dc.title[].value
Non-equilibrium steady state phase transitions of various statistical models

# _embedded.searchResult._embedded.objects[]._embedded.indexableObject.name
Maraş Kara Lise tarihi ve türk edebiyatına katkıları

# _embedded.searchResult._embedded.objects[]._embedded.indexableObject.metadata.dc.description[].value
Ankara : İhsan Doğramacı Bilkent Üniversitesi İktisadi, İdari ve Sosyal Bilimler Fakültesi, Tarih Bölümü, 2024.

# _embedded.searchResult._embedded.objects[]._embedded.indexableObject.metadata.dc.description[].value
This work is a student project of the Department of History, Faculty of Economics, Administrative and Social Sciences, İhsan Doğramacı Bilkent University.

# _embedded.searchResult._embedded.objects[]._embedded.indexableObject.metadata.dc.description[].value
The History of Turkey course (HIST200) is a requirement for all Bilkent undergraduates. It is designed to encourage students to work in groups on projects concerning any topic of their choice that relates to the history of Turkey. It is designed as an interactive course with an emphasis on research and the objective of investigating events, chronologically short historical periods, as well as historic representations. Students from all departments prepare and present final projects for examination by a committee, with 10 projects chosen to receive awards.

# _embedded.searchResult._embedded.objects[]._embedded.indexableObject.metadata.dc.description.abstract[].value
19. yüzyılda Osmanlı İmparatorluğu'nda eğitim, modernleşme sürecinin etkileriyle şekillenmiştir. Batılı tarzda eğitim kurumları ve müfredatıyla tanışma dönemi olan bu yıllarda, yabancı ülkelerin eğitim alanındaki faaliyetleri Osmanlı'da eğitim reformlarını etkilemiştir. Maraş Kara Lisesi, bu dönemde önemli bir eğitim kurumu olarak kurulmuş ve Cumhuriyet dönemine kadar eğitim faaliyetlerine devam etmiştir. Cumhuriyet sonrası dönemde Maraş Kara Lisesi'nin eğitim programları çeşitli alanlarda yoğunlaşmıştır. Lise, Erken Cumhuriyet döneminde modern eğitim anlayışını benimseyerek yeni müfredat ve öğretim yöntemleriyle öğrencilerine hizmet vermiştir. Zaman içinde, okulun eğitim programları ve içeriği çeşitli reformlarla şekillenmiş ve gelişmiştir. Ayrıca, Maraş Kara Lisesi'nin müze olma süreci ve depremler gibi doğal afetlerle karşılaşması da lisenin tarihinde önemli bir dönüm noktası olmuştur. Maraş Kara Lisesi'nin edebiyatla ilişkisi, özellikle "Yedi Güzel Adam" olarak bilinen edebiyatçılar üzerinden incelenmiştir. Bu edebiyatçılar, Türk edebiyatına önemli katkılarda bulunmuş ve dönemlerinin önde gelen isimleri arasında yer almışlardır. Yedi Güzel Adam'ın kimlikleri ve eserleri, Türk edebiyatının gelişimine etkileri üzerinde detaylı bir şekilde durulmuştur. Maraş Kara Lisesi'nin bu edebiyatçılarla olan ilişkisi, Türk kültür ve edebiyat tarihine önemli bir perspektif sunmaktadır.

# _embedded.searchResult._embedded.objects[]._embedded.indexableObject.metadata.dc.description.abstract[].value
Modernization in the 19th century: Western-style educational institutions and curricula influenced the Ottoman Empire. Foreign activities influenced educational reforms in the Ottoman Empire in education. Maraş Kara High School, one of the essential high schools inthis period, continued its educational activity as a high school in the republican period. In thispost-Republic period, education programs at Maraş Kara High School also specialized insome areas. The Turkish Republic was founded with many reforms, improvements, andsignificant progress in every area, including the educational programs and content of theschool in the Early Republican period. The school started serving its students with a moderneducation approach, using new curricula and teaching techniques. Finally, history has writtenthat Maraş Kara High School was turned into a museum, and in its existence, significantmagnitudes of natural disasters such as earthquakes took place. This study examined therelationship of Maraş Kara High School to the writers, the importance to the members of theliterary figures, and the called "Yedi Güzel Adam." Indeed, they were the critical actors inTurkish literature at that time. Their identities and works were analyzed in detail, thusshowing their influence on the development of Turkish literature. The association of theMaraş Kara High School with these literary figures is vital to acquiring an in-depthperspective of Turkish cultural and literary history.

# _embedded.searchResult._embedded.objects[]._embedded.indexableObject.metadata.dc.title[].value
Maraş Kara Lise tarihi ve türk edebiyatına katkıları

# _embedded.facets[]._embedded.values[].label
Department of Electrical and Electronics Engineering

# _embedded.facets[]._embedded.values[].label
Institute of Materials Science and Nanotechnology (UNAM)