Show simple item record

dc.contributor.authorGoodwill, P.en_US
dc.contributor.authorSarıtaş, Emine Ülküen_US
dc.contributor.authorCroft, L.en_US
dc.contributor.authorKim, T.en_US
dc.contributor.authorKrishnan, K.en_US
dc.contributor.authorSchaffer, D.en_US
dc.contributor.authorConolly, S.en_US
dc.date.accessioned2020-04-10T08:57:07Z
dc.date.available2020-04-10T08:57:07Z
dc.date.issued2012
dc.identifier.issn1521-4095
dc.identifier.urihttp://hdl.handle.net/11693/53587
dc.description.abstractOne quarter of all iodinated contrast X‐ray clinical imaging studies are now performed on Chronic Kidney Disease (CKD) patients. Unfortunately, the iodine contrast agent used in X‐ray is often toxic to CKD patients’ weak kidneys, leading to significant morbidity and mortality. Hence, we are pioneering a new medical imaging method, called Magnetic Particle Imaging (MPI), to replace X‐ray and CT iodinated angiography, especially for CKD patients. MPI uses magnetic nanoparticle contrast agents that are much safer than iodine for CKD patients. MPI already offers superb contrast and extraordinary sensitivity. The iron oxide nanoparticle tracers required for MPI are also used in MRI, and some are already approved for human use, but the contrast agents are far more effective at illuminating blood vessels when used in the MPI modality. We have recently developed a systems theoretic framework for MPI called x‐space MPI, which has already dramatically improved the speed and robustness of MPI image reconstruction. X‐space MPI has allowed us to optimize the hardware for five MPI scanners. Moreover, x‐space MPI provides a powerful framework for optimizing the size and magnetic properties of the iron oxide nanoparticle tracers used in MPI. Currently MPI nanoparticles have diameters in the 10‐20 nanometer range, enabling millimeter‐scale resolution in small animals. X‐space MPI theory predicts that larger nanoparticles could enable up to 250 micrometer resolution imaging, which would represent a major breakthrough in safe imaging for CKD patients.en_US
dc.language.isoEnglishen_US
dc.source.titleAdvanced Materialsen_US
dc.relation.isversionofhttps://doi.org/10.1002/adma.201200221en_US
dc.titleX‐Space MPI: magnetic nanoparticles for safe medical imagingen_US
dc.typeArticleen_US
dc.departmentAysel Sabuncu Brain Research Center (BAM)en_US
dc.citation.spage3870en_US
dc.citation.epage3877en_US
dc.citation.volumeNumber24en_US
dc.citation.issueNumber28en_US
dc.identifier.doi10.1002/adma.201200221en_US
dc.publisherWileyen_US
dc.contributor.bilkentauthorSarıtaş, Emine Ülkü


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record