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dc.contributor.authorAdams, Michelle M.en_US
dc.contributor.authorForbes, Men_US
dc.contributor.authorLinville, M.en_US
dc.contributor.authorRiddle, D.en_US
dc.contributor.authorSonntag, W.en_US
dc.contributor.authorBrunso-Bechtold, J.en_US
dc.date.accessioned2020-04-06T13:13:56Z
dc.date.available2020-04-06T13:13:56Z
dc.date.issued2009
dc.identifier.issn0897-7194
dc.identifier.urihttp://hdl.handle.net/11693/53552
dc.description.abstractInsulin-like growth factor-I (IGF-I), a functionally important neurotrophic factor, impacts tissues throughout the body including the central nervous system. In addition to the significant proportion of IGF-I that is synthesized in the liver and released into the plasma, IGF-I is expressed locally in tissues. The present study investigated the relationship between plasma and local brain levels of IGF-I in two well-characterized models of decreased IGF-I. The first is an adult-onset growth hormone deficiency (AOGHD) model, and the second is a caloric restriction (CR) model. In the first cohort of animals from both models, the hippocampus was removed from the brain immediately following decapitation, and in the second cohort, the animals were perfused transcardially with phosphate buffered saline to remove cerebral blood prior to harvesting the hippocampus. Our results demonstrated that although the plasma IGF-I levels were decreased in the CR and AOGHD rats compared to controls, the hippocampal IGF-I levels did not differ among the groups. These data suggest that local brain IGF-I levels are regulated in a different manner than plasma IGF-I levels.en_US
dc.language.isoEnglishen_US
dc.source.titleGrowth Factorsen_US
dc.relation.isversionofhttps://doi.org/10.1080/08977190902863639en_US
dc.subjectCaloric restrictionen_US
dc.subjectDwarf raten_US
dc.subjectHippocampusen_US
dc.subjectFischer 344 × Brown Norway raten_US
dc.subjectGrowth hormoneen_US
dc.titleStability of local brain levels of insulin-like growth factor-I in two well-characterized models of decreased plasma IGF-Ien_US
dc.typeArticleen_US
dc.departmentAysel Sabuncu Brain Research Center (BAM)en_US
dc.citation.spage181en_US
dc.citation.epage188en_US
dc.citation.volumeNumber27en_US
dc.citation.issueNumber3en_US
dc.identifier.doi10.1080/08977190902863639en_US
dc.publisherTaylor & Francisen_US
dc.contributor.bilkentauthorAdams, Michelle M.


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