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Materials for articular cartilage regeneration
(Bentham Science Publishers B.V., 2012)
Many health problems remaining to be untreatable throughout the human history can be overcome by utilizing new biomedical materials. Healing cartilage defects is one of the problems causing significant health issue due to ...
Neural differentiation on synthetic scaffold materials
(Royal Society of Chemistry, 2013)
The potential of stem cells to differentiate into a variety of subgroups of neural cells makes stem cell differentiation and transplantation a promising candidate for neurodegenerative disorder therapies. However, selective ...
Mitochondrial serine protease HTRA2 p.G3999S in a kindred with essential tremor and Parkinson disease
(National Academy of Sciences, 2014)
Essential tremor is one of the most frequent movement disorders of humans and can be associated with substantial disability. Some but not all persons with essential tremor develop signs of Parkinson disease, and the ...
Generation of chimeric "aBS nanohemostat" complex and comparing its histomorphological in vivo effects to the traditional ankaferd hemostat in controlled experimental partial nephrectomy model
(Hindawi, 2013)
Purpose. Using the classical Ankaferd Blood Stopper (ABS) solution to create active hemostasis during partial nephrectomy (PN) may not be so effective due to insufficient contact surface between the ABS hemostatic liquid ...
Growth and differentiation of prechondrogenic cells on bioactive self-assembled peptide nanofibers
(American Chemical Society, 2013)
Restoration of cartilage defect remains a challenge, as the current treatments are ineffective to return tissue to its health. Thus, developing therapies for treatment of cartilage tissue damage caused by common joint ...
Growth factor binding on heparin mimetic peptide nanofibers
(American Chemical Society, 2012)
Immobilization of growth factors in scaffolds is important for controlling their dose and bioactivity for regenerative medicine applications. Although numerous covalent and noncovalent immobilization strategies have been ...
Neural ECM mimetics
(Elsevier, 2014)
The consequence of numerous neurological disorders is the significant loss of neural cells, which further results in multilevel dysfunction or severe functional deficits. The extracellular matrix (ECM) is of tremendous ...
Extracellular matrix mimetic peptide scaffolds for neural stem cell culture and differentiation
(Humana Press, 2014)
Self-assembled peptide nanofibers form three-dimensional networks that are quite similar to fibrous extracellular matrix (ECM) in their physical structure. By incorporating short peptide sequences derived from ECM proteins, ...
Bioactive self-assembled peptide nanofibers for corneal stroma regeneration
(Elsevier, 2014)
Defects in the corneal stroma caused by trauma or diseases such as macular corneal dystrophy and keratoconus can be detrimental for vision. Development of therapeutic methods to enhance corneal regeneration is essential ...
Tenascin-C mimetic peptide nanofibers direct stem cell differentiation to osteogenic lineage
(American Chemical Society, 2014)
Extracellular matrix contains various signals for cell surface receptors that regulate cell fate through modulation of cellular activities such as proliferation and differentiation. Cues from extracellular matrix components ...