Browsing Aysel Sabuncu Brain Research Center (BAM) by Issue Date
Now showing items 1-20 of 249
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Functional characterization of Des-IGF-1 action at excitatory synapses in the CA1 region of rat hippocampus
(American Physiological Society, 2005)Insulin-like growth factor-1 (IGF-1) and growth hormone play a major role in the growth and development of tissues throughout the mammalian body. Plasma IGF-1 concentrations peak during puberty and decline with age. We ... -
Spatial learning and memory deficits after whole-brain irradiation are associated with changes in nmda receptor subunits in the hippocampus
(Radiation Research Society., 2006)Whole-brain irradiation is used for the treatment of brain tumors, but can it also induce neural changes, with progressive dementia occurring in 20–50% of long-term survivors. The present study investigated whether 45 Gy ... -
Meta- and paracontrast reveal differences between contour- and brightness-processing mechanisms
(Elsevier, 2006)We investigated meta- and paracontrast masking using tasks requiring observers to judge the surface brightness or else the contours of target stimuli. The contour task revealed strongest metacontrast at SOAs shorter than ... -
Caloric restriction eliminates the aging-related decline in NMDA and AMPA receptor subunits in the rat hippocampus and induces homeostasis
(ElsevierAysel Sabuncu Brain Research Center (BAM), 2007)Caloric restriction (CR) extends life span and ameliorates the aging-related decline in hippocampal-dependent cognitive function. In the present study, we compared subunit levels of NMDA and AMPA types of the glutamate ... -
Attention-dependent representation of a size illusion in human V1
(Cell Press, 2008)One of the most fundamental properties of human primary visual cortex (V1) is its retinotopic organization, which makes it an ideal candidate for encoding spatial properties, such as size, of objects. However, three-dimensional ... -
Full‐brain coverage and high‐resolution imaging capabilities of passband b‐SSFP fMRI at 3T
(Wiley‐Liss, Inc., 2008)Passband balanced-steady-state free precession (b-SSFP)fMRI is a recently developed method that utilizes the passband(flat portion) of the b-SSFP off-resonance response to measureMR signal changes elicited by changes in ... -
Metacontrast masking and stimulus contrast polarity
(Elsevier, 2008)A recent report [Becker, M. W., & Anstis S. (2004). Metacontrast masking is specific to luminance polarity. Vision Research, 44, 2537–2543] of a failure to obtain metacontrast with target and mask stimuli of opposite ... -
Estrogen and aging affect synaptic distribution of phosphorylated LIM kinase (pLIMK) in CA1 region of female rat hippocampus
(Elsevier, 2008)17β-Estradiol (E) increases axospinous synapse density in the hippocampal CA1 region of young female rats, but not in aged rats. This may be linked to age-related alterations in signaling pathways activated by synaptic ... -
Distinct perceptual grouping pathways revealed by temporal carriers and envelopes
(Association for Research in Vision and Ophthalmology, 2008)S. E. Guttman, L. A. Gilroy, and R. Blake (2005) investigated whether observers could perform temporal grouping in multi-element displays where each local element was stochastically modulated over time along one of several ... -
Border ownership selectivity in human early visual cortex and its modulation by attention
(Society for Neuroscience, 2009)Natural images are usually cluttered because objects occlude one another. A critical aspect of recognizing these visual objects is to identify the borders between image regions that belong to different objects. However, ... -
Stability of local brain levels of insulin-like growth factor-I in two well-characterized models of decreased plasma IGF-I
(Taylor & Francis, 2009)Insulin-like growth factor-I (IGF-I), a functionally important neurotrophic factor, impacts tissues throughout the body including the central nervous system. In addition to the significant proportion of IGF-I that is ... -
Effects of contrast polarity in paracontrast masking
(Springer New York, 2009)The visibility of a target stimulus can be suppressed (inhibition) or increased (facilitation) during paracontrast masking. Three processes have been proposed to be involved in paracontrast masking: brief inhibition, ... -
Perceived glossiness in high dynamic range scenes
(Association for Research in Vision and Ophthalmology, 2010)We investigated how spatial pattern, background, and dynamic range affect perceived gloss in brightly lit real scenes. Observers viewed spherical objects against uniform backgrounds. There were three possible objects. Two ... -
Age-related synapse loss in hippocampal CA3 is not reversed by caloric restriction
(Pergamon Press, 2010)Caloric restriction (CR) is a reduction of total caloric intake without a decrease in micronutrients or a disproportionate reduction of any one dietary component. While CR attenuates age-related cognitive deficits in tasks ... -
Perceptual grouping-dependent lightness processing in human early visual cortex
(Association for Research in Vision and Ophthalmology, 2010)Lightness, the perceived relative achromatic reectance of a surface, depends strongly on the context within which the surface is viewed. Modest changes in the two-dimensional conguration or three-dimensional scene geometry ... -
Estimating the glossiness transfer function induced by illumination change and testing its transitivity
(Association for Research in Vision and Ophthalmology, 2010)The light reflected from a glossy surface depends on the reflectance properties of that surface as well as the flow of light in the scene, the light field. We asked four observers to compare the glossiness of pairs of ... -
Perceptual asynchronies and the dual-channel differential latency hypothesis
(Cambridge University Press, 2010)The dual-channel differential latency hypothesis (Öğmen et al. 2004) successfully accounts for many aspects of the flash-lag effect (FLE). Here we use the dual-channel differential latency hypothesis to explain an illusion ... -
Auditory modulation of visual apparent motion with short spatial and temporal intervals
(Association for Research in Vision and Ophthalmology, 2010)Recently, E. Freeman and J. Driver (2008) reported a cross-modal temporal interaction in which brief sounds drive the perceived direction of visual apparent-motion, an effect they attributed to “temporal capture” of the ... -
Slow release and delivery of antisense oligonucleotide drug by self-assembled peptide amphiphile nanofibers
(American Chemical Society, 2011)Antisense oligonucleotides provide a promising therapeutic approach for several disorders including cancer. Chemical stability, controlled release, and intracellular delivery are crucial factors determining their efficacy. ... -
Nanomechanical characterization by double-pass force-distance mapping
(Institute of Physics Publishing, 2011)We demonstrate high speed force-distance mapping using a double-pass scheme. The topography is measured in tapping mode in the first pass and this information is used in the second pass to move the tip over the sample. In ...
