Now showing items 115-134 of 183

    • N-cadherin mimetic peptide nanofiber system induces chondrogenic differentiation of mesenchymal stem cells 

      Çimenci, Çağla Eren; Uzunalli-Kurtuluş, G.; Çalışkan, Özüm S.; Güler, M. O.; Tekinay, Ayşe B. (American Chemical Society, 2019)
      Cadherins are vital for cell-to-cell interactions during tissue growth, migration, and differentiation processes. Both biophysical and biochemical inputs are generated upon cell-to-cell adhesions, which determine the fate ...
    • Nanomechanical characterization by double-pass force-distance mapping 

      Dagdas, Yavuz S.; Aslan, M. N.; Tekinay, Ayse B.; Güler, Mustafa O.; Dâna, Aykutlu (Institute of Physics Publishing, 2011)
      We demonstrate high speed force-distance mapping using a double-pass scheme. The topography is measured in tapping mode in the first pass and this information is used in the second pass to move the tip over the sample. In ...
    • Neural differentiation on synthetic scaffold materials 

      Mammadov, Busra; Sever, Melike; Güler, Mustafa O.; Tekinay, Ayşe B. (Royal Society of Chemistry, 2013)
      The potential of stem cells to differentiate into a variety of subgroups of neural cells makes stem cell differentiation and transplantation a promising candidate for neurodegenerative disorder therapies. However, selective ...
    • Neural ECM mimetics 

      Estrada, V.; Tekinay, Ayşe B.; Müller, H. W. (Elsevier, 2014)
      The consequence of numerous neurological disorders is the significant loss of neural cells, which further results in multilevel dysfunction or severe functional deficits. The extracellular matrix (ECM) is of tremendous ...
    • Neurochemical differences between bipolar disorder type I and II in superior temporal cortices: a proton magnetic resonance spectroscopy study 

      Atagün, M. İ.; Şıkoğlu, E. M.; Can, S. S.; Uğurlu, G. K.; Kaymak, S. U.; Çayköylü, A.; Algın, Oktay; Phillips, M. L.; Moore, C. M.; Öngür, D. (Elsevier B.V., 2018)
      Background: Despite the diagnostic challenges in categorizing bipolar disorder subtypes, bipolar I and II disorders (BD-I and BD-II respectively) are valid indices for researchers. Subtle neurobiological differences may ...
    • A new class of cubic SPIONs as a dual-mode T1 and T2 contrast agent for MRI 

      Alipour, Akbar; Soran-Erdem, Zeliha; Utkur, Mustafa; Sharma, Vijay Kumar; Algın, Oktay; Sarıtaş, Emine Ülkü; Demir, Hilmi Volkan (Elsevier, 2018)
      Superparamagnetic iron oxide nanoparticles (SPIONs) are widely used as a robust negative contrast agent on conventional MRI. In this study, we (a) synthesized a new class of cubic SPIONs as a dual-mode contrast agent in ...
    • Novel object recognition is not affected by age despite age-related brain changes 

      Aktoprak, İlay; Dinç, Pelin; Günay, Gizem; Adams, Michelle M. (Scientific Research Publishing, 2013)
      Age-related memory impairments show a progressive decline across lifespan. Studies have demonstrated equivocal results in biological and behavioral outcomes of aging. Thus, in the present study we examined the novel object ...
    • A novel, low-cost Anesthesia and injection system for Zebrafish Researchers 

      Oskay, Y.; Çetin B.; Şerifoğlu, Naz; Arslan-Ergül, Ayça; Adams, Michelle M. (Mary Ann Liebert, Inc. Publishers, 2018)
      In this study, we designed and developed a novel low-cost system for anesthetizing and injecting adult zebrafish. The system utilizes a gradual cooling method for the anesthesia and maintains the fish in a stable anesthetic ...
    • Object-oriented segmentation of cell nuclei in fluorescence microscopy images 

      Koyuncu, Can Fahrettin; Cetin Atalay, R.; Gunduz Demir, Cigdem (Wiley-Liss, 2018)
      Cell nucleus segmentation remains an open and challenging problem especially to segment nuclei in cell clumps. Splitting a cell clump would be straightforward if the gradients of boundary pixels in-between the nuclei were ...
    • Oligonucleotide delivery with cell surface binding and cell penetrating peptide amphiphile nanospheres 

      Mumcuoğlu, Didem; Sardan, Melis; Tekinay, T.; Güler, Mustafa O.; Tekinay, Ayşe. B. (American Chemical Society, 2015)
      A drug delivery system designed specifically for oligonucleotide therapeutics can ameliorate the problems associated with the in vivo delivery of these molecules. The internalization of free oligonudeotides is challenging, ...
    • Optimizing electrode montages of transcranial direct current stimulation for attentional bias modification in early abstinent methamphetamine users 

      Shahbabaie, A.; Hatami, J.; Farhoudian, A.; Ekhtiari, H.; Khatibi, A.; Nitsche, M. A. (Frontiers Media S.A., 2018)
      Introduction: Chronic use of most psychoactive drugs may lead to substance dependence and drug addiction. Drug addiction is a chronically relapsing disorder, and current pharmacological and behavioral therapies are not ...
    • Osteoselection supported by phase separated polymer blend films 

      Gülsuner, Hilal Unal; Gengec, N. A.; Kılınç, Murat; Erbil, H. Y.; Tekinay, Ayse B. (Wiley, 2015)
      The instability of implants after placement inside the body is one of the main obstacles to clinically succeed in periodontal and orthopedic applications. Adherence of fibroblasts instead of osteoblasts to implant surfaces ...
    • Peptide nanofiber scaffolds for multipotent stromal cell culturing 

      Üstün, Seher; Kocabey, Samet; Güler, Mustafa O.; Tekinay, Ayse B. (Humana Press Inc., 2013)
      Self-assembled peptide nanofibers are versatile materials providing suitable platforms for regenerative medicine applications. This chapter describes the use of peptide nanofibers as extracellular matrix mimetic scaffolds ...
    • Peptide-based materials for cartilage tissue regeneration 

      Hastar, Nurcan; Arslan, Elif.; Güler, Mustafa O.; Tekinay, Ayse B. (Springer New York LLC, 2017)
      Cartilaginous tissue requires structural and metabolic support after traumatic or chronic injuries because of its limited capacity for regeneration. However, current techniques for cartilage regeneration are either invasive ...
    • Perceived glossiness in high dynamic range scenes 

      Doerschner, K.; Maloney,Laurence T.; Boyaci, Hüseyin (Association for Research in Vision and Ophthalmology, 2010)
      We investigated how spatial pattern, background, and dynamic range affect perceived gloss in brightly lit real scenes. Observers viewed spherical objects against uniform backgrounds. There were three possible objects. Two ...
    • Perceptual asynchronies and the dual-channel differential latency hypothesis 

      Kafalıgönül, Hulusi; Patel, S.; Öğmen, H.; Bedell, H.; Purushothaman, G. (Cambridge University Press, 2010)
      The dual-channel differential latency hypothesis (Öğmen et al. 2004) successfully accounts for many aspects of the flash-lag effect (FLE). Here we use the dual-channel differential latency hypothesis to explain an illusion ...
    • Perceptual averaging in individuals with autism spectrum disorder 

      Corbett,, Jennifer Elise; Venuti, P.; Melcher, D. (Frontiers Research Foundation, 2016)
      There is mounting evidence that observers rely on statistical summaries of visual information to maintain stable and coherent perception. Sensitivity to the mean (or other prototypical value) of a visual feature (e.g., ...
    • Perceptual grouping-dependent lightness processing in human early visual cortex 

      Boyaci, H.; Fang, F.; Murray, S. O.; Kersten, D. (Association for Research in Vision and Ophthalmology, 2010)
      Lightness, the perceived relative achromatic reectance of a surface, depends strongly on the context within which the surface is viewed. Modest changes in the two-dimensional conguration or three-dimensional scene geometry ...
    • Phase-correcting non-local means filtering for diffusion-weighted imaging of the spinal cord 

      Kafali, Sevgi Gokce; Çukur, Tolga; Sarıtaş, Emine Ülkü (John Wiley & Sons, 2018)
      Purpose: DWI suffers from low SNR when compared to anatomical MRI. To maintain reasonable SNR at relatively high spatial resolution, multiple acquisitions must be averaged. However, subject motion or involuntary physiological ...
    • Phase-sensitive reconstruction for fat-water separation in multi-coil acquisitions 

      Yılmaz, Özgür; Sarıtaş, Emine Ülkü; Çukur, Tolga (IEEE, 2016)
      Phase-sensitive steady-state free precession (PS-SSFP) is an effective technique for separating fat and water tissues, based on the phase difference between balanced steady-state free precession (bSSFP) bands. However, in ...