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dc.contributor.authorFaitot, F.en_US
dc.contributor.authorRuhland, E.en_US
dc.contributor.authorOncioiu, C.en_US
dc.contributor.authorBesch, C.en_US
dc.contributor.authorAddeo, P.en_US
dc.contributor.authorÇiçek, A. Ercümenten_US
dc.contributor.authorBachellier, P.en_US
dc.contributor.authorNamer, I. -J.en_US
dc.description.abstractBackground Posthepatectomy liver failure (PHLF) is the main limitation to extending liver resection but its pathophysiology is not yet fully understood. The aim of the study was to describe the metabolic adaptations that occur with PHLF. Methods A retrospective study of 82 patients using nuclear magnetic resonance metabolomics to identify and quantify intra-hepatic metabolites was performed. The metabolite levels were compared using metabolic network analysis ADEMA between fatal PHLF (FLF) and non fatal PHLF and according to PHLF/ACLF grading. Results Metabolomic profiles were significantly different between patients presenting FLF and non FLF or grade 3 ACLF versus < grade 3 ACLF. In the patients undergoing hepatectomy, valine, alanine and glycerophosphocholine were identified as powerful biomarkers to predict FLF (AUROC 0.806, 0.802 and 0.856 respectively). Network analysis showed an activation of aerobic glycolysis with glutaminolysis as observed in highly proliferating systems. Inversely, ACLF3 showed deprivation of glucose and lactate compared to lower ACLF grade. Conclusion Clinical andbiological severity of ACLF and PHLF correlate with specific metabolic adaptations. Metabolomics can predict fatal liver failure after hepatectomy and underline significant differences in the metabolic patterns of ACLF and PHLF.en_US
dc.source.titleHPB Journal ( Hepato-Pactreato-Biliary)en_US
dc.titleMetabolomic profiling highlights the metabolic bases of acute-on-chronic and post-hepatectomy liver failureen_US
dc.departmentDepartment of Computer Engineeringen_US
dc.contributor.bilkentauthorÇiçek, A. Ercüment

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