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dc.contributor.authorDönmez, Selin E.en_US
dc.contributor.authorSoydaş, E.en_US
dc.contributor.authorAydın, Gökçenen_US
dc.contributor.authorŞahin, O.en_US
dc.contributor.authorBozkaya, U.en_US
dc.contributor.authorTürkmen, Yunus Emreen_US
dc.date.accessioned2020-02-12T12:53:29Z
dc.date.available2020-02-12T12:53:29Z
dc.date.issued2019
dc.identifier.issn1523-7060
dc.identifier.urihttp://hdl.handle.net/11693/53318
dc.description.abstractA catalytic aza-Nazarov cyclization between 3,4-dihydroisoquinolines and α,β-unsaturated acyl chlorides has been developed to access α-methylene-γ-lactam products in good yields (up to 79%) as single diastereomers. The reactions proceed efficiently when AgOTf is used as an anion exchange catalyst with a 20 mol % loading at 80 °C. Computational studies were performed to investigate the reaction mechanism, and the findings support the role of the −TMS group in reducing the reaction barrier of the key cyclization step.en_US
dc.language.isoEnglishen_US
dc.source.titleOrganic Lettersen_US
dc.relation.isversionofhttps://dx.doi.org/10.1021/acs.orglett.8b03886en_US
dc.subjectChemical reactionsen_US
dc.subjectAnionsen_US
dc.subjectAcylsen_US
dc.subjectCyclization Cationsen_US
dc.titleAza-Nazarov cyclization reactions via anion exchange catalysisen_US
dc.typeArticleen_US
dc.departmentDepartment of Chemistryen_US
dc.departmentInstitute of Materials Science and Nanotechnology (UNAM)en_US
dc.departmentNanotechnology Research Center (NANOTAM)en_US
dc.citation.spage554en_US
dc.citation.epage558en_US
dc.citation.volumeNumber21en_US
dc.citation.issueNumber2en_US
dc.identifier.doi10.1021/acs.orglett.8b03886en_US
dc.publisherAmerican Chemical Societyen_US
dc.contributor.bilkentauthorDönmez, Selin E.
dc.contributor.bilkentauthorAydın, Gökçen
dc.contributor.bilkentauthorTürkmen, Yunus Emre


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