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dc.contributor.authorBüyükdağlı, Şahinen_US
dc.contributor.authorSarabadani, J.en_US
dc.contributor.authorAla-Nissila, T.en_US
dc.date.accessioned2020-01-24T11:42:25Z
dc.date.available2020-01-24T11:42:25Z
dc.date.issued2019
dc.identifier.issn2073-4360
dc.identifier.urihttp://hdl.handle.net/11693/52806
dc.description.abstractThe theoretical formulation of driven polymer translocation through nanopores is complicated by the combination of the pore electrohydrodynamics and the nonequilibrium polymer dynamics originating from the conformational polymer fluctuations. In this review, we discuss the modeling of polymer translocation in the distinct regimes of short and long polymers where these two effects decouple. For the case of short polymers where polymer fluctuations are negligible, we present a stiff polymer model including the details of the electrohydrodynamic forces on the translocating molecule. We first show that the electrohydrodynamic theory can accurately characterize the hydrostatic pressure dependence of the polymer translocation velocity and time in pressure-voltage-driven polymer trapping experiments. Then, we discuss the electrostatic correlation mechanisms responsible for the experimentally observed DNA mobility inversion by added multivalent cations in solid-state pores, and the rapid growth of polymer capture rates by added monovalent salt in α-Hemolysin pores. In the opposite regime of long polymers where polymer fluctuations prevail, we review the iso-flux tension propagation (IFTP) theory, which can characterize the translocation dynamics at the level of single segments. The IFTP theory is valid for a variety of polymer translocation and pulling scenarios. We discuss the predictions of the theory for fully flexible and rodlike pore-driven and end-pulled translocation scenarios, where exact analytic results can be derived for the scaling of the translocation time with chain length and driving force.en_US
dc.language.isoEnglishen_US
dc.source.titlePolymersen_US
dc.relation.isversionofhttps://doi.org/10.3390/polym11010118en_US
dc.subjectPolymer translocationen_US
dc.subjectDielectric membranesen_US
dc.subjectElectrostatic interactionsen_US
dc.subjectCharge screeningen_US
dc.titleTheoretical modeling of polymer translocation: from the electrohydrodynamics of short polymers to the fluctuating long polymersen_US
dc.typeReviewen_US
dc.departmentDepartment of Physicsen_US
dc.citation.volumeNumber11en_US
dc.citation.issueNumber1en_US
dc.identifier.doi10.3390/polym11010118en_US
dc.publisherMDPI AGen_US
dc.contributor.bilkentauthorBüyükdağlı, Şahin


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