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dc.contributor.authorKumar, Y.en_US
dc.contributor.authorBedi, P. M. S.en_US
dc.contributor.authorSingh, P.en_US
dc.contributor.authorAdeniyi, A. A.en_US
dc.contributor.authorSingh-Pillay, A.en_US
dc.contributor.authorSingh, P.en_US
dc.contributor.authorBhargava, G.en_US
dc.date.accessioned2019-02-21T16:03:12Z
dc.date.available2019-02-21T16:03:12Z
dc.date.issued2018en_US
dc.identifier.urihttp://hdl.handle.net/11693/50084
dc.description.abstractThe manuscript describes a straightforward and atom-efficient method for the synthesis of α-alkylidene-β-lactams using sorbyl tosylate and imines/1-azadienes at high temperature (80 °C). The Density functional theory calculations have shown the prevalence of the first order kinetics in these [2+2] cycloadditions to produce mixture of 3-butadienyl-azetidin-2ones and 3-but-2-enylidene-azetidin-2-ones in good yields. The 3-but-2-enylidene-azetidin-2-ones have also shown antimicrobial activity against the E. coli, S. aureus, P. aeruginosa, B. cereus and B. subtilis.
dc.language.isoEnglish
dc.source.titleChemistrySelecten_US
dc.relation.isversionofhttps://doi.org/10.1002/slct.201801605
dc.subjectAzadieneen_US
dc.subjectButadienylketeneen_US
dc.subjectSpirocyclesen_US
dc.subjectα-alkylidene-β-lactamen_US
dc.subjectβ-lactamen_US
dc.title[2+2] cycloadditions of sorbyl tosylate with imines/1-azadienes: a one-pot domino approach for α-alkylidene-β-lactams and their computational studies and antimicrobial evaluationen_US
dc.typeArticleen_US
dc.departmentNanotechnology Research Center (NANOTAM)en_US
dc.departmentInstitute of Materials Science and Nanotechnology (UNAM)en_US
dc.departmentDepartment of Chemistryen_US
dc.citation.spage9484en_US
dc.citation.epage9492en_US
dc.citation.volumeNumber3en_US
dc.citation.issueNumber32en_US
dc.identifier.doi10.1002/slct.201801605
dc.publisherWiley-Blackwell
dc.embargo.release2019-08-31en_US
dc.identifier.eissn2365-6549


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