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dc.contributor.authorAtagün, M. İ.en_US
dc.contributor.authorŞıkoğlu, E. M.en_US
dc.contributor.authorCan, S. S.en_US
dc.contributor.authorUğurlu, G. K.en_US
dc.contributor.authorKaymak, S. U.en_US
dc.contributor.authorÇayköylü, A.en_US
dc.contributor.authorAlgın, Oktayen_US
dc.contributor.authorPhillips, M. L.en_US
dc.contributor.authorMoore, C. M.en_US
dc.contributor.authorÖngür, D.en_US
dc.date.accessioned2019-02-21T16:01:39Z
dc.date.available2019-02-21T16:01:39Z
dc.date.issued2018en_US
dc.identifier.issn0165-0327
dc.identifier.urihttp://hdl.handle.net/11693/49892
dc.description.abstractBackground: Despite the diagnostic challenges in categorizing bipolar disorder subtypes, bipolar I and II disorders (BD-I and BD-II respectively) are valid indices for researchers. Subtle neurobiological differences may underlie clinical differences between mood disorder subtypes. The aims of this study were to investigate neurochemical differences between bipolar disorder subtypes. Methods: Euthymic BD-II patients (n = 21) are compared with BD-I (n = 28) and healthy comparison subjects (HCs, n = 30). Magnetic Resonance Imaging (MRI) and proton spectroscopy (1H MRS) were performed on a 3T Siemens Tim Trio system. MRS voxels were located in the left/right superior temporal cortices, and spectra acquired with the single voxel Point REsolved Spectroscopy Sequence (PRESS). The spectroscopic data were analyzed with LCModel (Version 6.3.0) software. Results: There were significant differences between groups in terms of glutamate [F = 6.27, p = 0.003], glutamate + glutamine [F = 6.08, p = 0.004], inositol containing compounds (Ino) (F = 9.25, p < 0.001), NAA [F = 7.63, p = 0.001] and creatine + phosphocreatine [F = 11.06, p < 0.001] in the left hemisphere and Ino [F = 5.65, p = 0.005] in the right hemisphere. Post-hoc comparisons showed that the BD-I disorder group had significantly lower metabolite levels in comparison to the BD-II and the HC groups. Limitations: This was a cross-sectional study with a small sample size. In addition, patients were on various psychotropic medications, which may have impacted the results. Conclusions: Neurochemical levels, in the superior temporal cortices, measured with 1H-MRS discriminated between BD-II and BD-I. Although further studies are needed, one may speculate that the superior temporal cortices (particularly left hemispheric) play a critical role, whose pathology may be related to subtyping bipolar disorder.
dc.description.sponsorshipThe study was funded by Scientific Research Projects Committee of the Ankara Yıldırım Beyazıt University (Project Code: 803) and NIMH grant to CMM ( MH073998 ) and NIH grant to DO K24 ( MH104449 ). Dr. Phillips acknowledged the support of the Pittsburgh Foundation.
dc.language.isoEnglish
dc.source.titleJournal of Affective Disordersen_US
dc.relation.isversionofhttps://doi.org/10.1016/j.jad.2018.04.010
dc.subjectBipolar disorderen_US
dc.subjectMagnetic resonance spectroscopyen_US
dc.subjectSuperior temporal gyrusen_US
dc.titleNeurochemical differences between bipolar disorder type I and II in superior temporal cortices: a proton magnetic resonance spectroscopy studyen_US
dc.typeArticleen_US
dc.departmentInterdisciplinary Program in Neuroscience (NEUROSCIENCE)en_US
dc.departmentAysel Sabuncu Brain Research Center (BAM)en_US
dc.citation.spage15en_US
dc.citation.epage19en_US
dc.citation.volumeNumber235en_US
dc.relation.projectCenter on the Microenvironment and Metastasis, Cornell University, CMM: MH073998 - Pittsburgh Foundation, TPF - National Institutes of Health, NIH: MH104449 - National Institute of Mental Health, NIMH - 803
dc.identifier.doi10.1016/j.jad.2018.04.010
dc.publisherElsevier B.V.
dc.contributor.bilkentauthorAlgın, Oktay
dc.embargo.release2019-08-01en_US


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