Interdisciplinary Program in Neuroscience

Effects of duty cycle on magnetostimulation thresholds in MPI

Demirel, O. B.; Saritas, E. U. (Infinite Science Publishing, 2017)

Magnetic Particle Imaging (MPI) relies on time-varying magnetic fields to generate an image of the spatial distribution of superparamagnetic iron oxide nanoparticles. However, these oscillating magnetic fields form electric ...

Comparison of system-matrix-based and projection-based reconstructions for field free line magnetic particle imaging

Ilbey, S.; Top, C. B.; Güngör, A.; Çukur, T.; Saritas, E. U.; Güven, H. E. (Infinite Science Publishing, 2017)

In magnetic particle imaging (MPI), system sensitivity can be enhanced by scanning the sample along a field free line (FFL) instead of a field free point (FFP). FFL MPI data can then be processed via system-matrix or ...

Cartilage endplate thickness variation measured by ultrashort echo-time MRI is associated with adjacent disc degeneration

Berg-Johansen, B.; Han, M.; Fields, A. J.; Liebenberg, E. C.; Lim, B. J.; Larson, P. E. Z.; Gunduz-Demir, C.; Kazakia, G. J.; Krug, R.; Lotz, J. C. (Lippincott Williams & Wilkins, 2018)

Study design: A magnetic resonance imaging study of human cadaver spines. Objective: To investigate associations between cartilage endplate (CEP) thickness and disc degeneration. Summary of background data: Damage to the ...

A modular antigen presenting peptide/oligonucleotide nanostructure platform for inducing potent immune response

Tohumeken, S.; Gunduz, N.; Demircan, M. B.; Gunay, G.; Topal, A. E.; Khalily, M. A.; Tekinay, T.; Dana, A.; Guler, M. O.; Tekinay, A. B. (Wiley - VCH Verlag GmbH & Co. KGaA, 2017-05)

The design and development of vaccines, which can induce cellular immunity, particularly CD8+ T cells hold great importance since these cells play crucial roles against cancers and viral infections. Covalent conjugation ...

Be precise and suffer less pain! a comment on “A brief intervention utilising visual feedback reduces pain and enhances tactile acuity in CLBP patients”

Khatibi, A. (IOS Press, 2016)

Fearful faces do not lead to faster attentional deployment in individuals with elevated psychopathic traits

Hoppenbrouwers, S. S.; Munneke, J.; Kooiman, K. A.; Little, B.; Neumann, C. S.; Theeuwes, J. (Springer New York LLC, 2017)

In the current study, a gaze-cueing experiment (similar to Dawel et al. 2015) was conducted in which the predictivity of a gaze-cue was manipulated (non-predictive vs highly predictive). This was done to assess the degree ...

Aging alters the molecular dynamics of synapses in a sexually dimorphic pattern in zebrafish (Danio rerio)

Karoglu, E. T.; Halim, D. O.; Erkaya, B.; Altaytas, F.; Arslan-Ergul, A.; Konu, O.; Adams, M. M. (Elsevier, 2017-06)

The zebrafish has become a popular model for studying normal brain aging due to its large fecundity, conserved genome, and available genetic tools; but little data exists about neurobiological age-related alterations. The ...

Supramolecular peptide nanofiber morphology affects mechanotransduction of stem cells

Arslan, E.; H. Koc, M.; Uysal, O.; Dikecoglu, B.; Topal, A. E.; Garifullin, R.; Ozkan, A. D.; Dana, A.; Hermida-Merino, D.; Castelletto, V.; Edwards-Gayle, C.; Baday, S.; Hamley, I.; Tekinay, A. B.; Guler, M. O. (American Chemical Society, 2017-08)

Chirality and morphology are essential factors for protein function and interactions with other biomacromolecules. Extracellular matrix (ECM) proteins are also similar to other proteins in this sense; however, the complexity ...

Antigenic GM3 Lactone Mimetic Molecule Integrated Mannosylated Glycopeptide Nanofibers for the Activation and Maturation of Dendritic Cells

Gunay G.; Sardan Ekiz M.; Ferhati X.; Richichi B.; Nativi C.; Tekinay A.B.; Guler M.O. (American Chemical Society, 2017)

The ability of dendritic cells to coordinate innate and adaptive immune responses makes them essential targets for vaccination strategies. Presentation of specific antigens by dendritic cells is required for the activation ...

Evolutionary psychology : A how - to guide

Lewis, D. M. S.; Al-Shawaf, L.; Conroy-Beam, D.; Asao, K.; Buss, D. M. (American Psychological Association Inc., 2017)

Researchers in the social and behavioral sciences are increasingly using evolutionary insights to test novel hypotheses about human psychology. Because evolutionary perspectives are relatively new to psychology and most ...

Intracellular Accumulation of Gold Nanoparticles Leads to Inhibition of Macropinocytosis to Reduce the Endoplasmic Reticulum Stress

Gunduz N.; Ceylan H.; Guler M.O.; Tekinay A.B. (Nature Publishing Group, 2017)

Understanding the toxicity of nanomaterials remains largely limited to acute cellular response, i.e., short-Term in vitro cell-death based assays, and analyses of tissue-and organ-level accumulation and clearance patterns ...

Diabetic wound regeneration using heparin-mimetic peptide amphiphile gel in db/db mice

Senturk B.; Demircan B.M.; Ozkan A.D.; Tohumeken S.; Delibasi T.; Guler M.O.; Tekinay A.B. (Royal Society of Chemistry, 2017)

There is an urgent need for more efficient treatment of chronic wounds in diabetic patients especially with a high risk of leg amputation. Biomaterials capable of presenting extracellular matrix-mimetic signals may assist ...

Presentation of functional groups on self-assembled supramolecular peptide nanofibers mimicking glycosaminoglycans for directed mesenchymal stem cell differentiation

Yasa O.; Uysal O.; Ekiz M.S.; Guler M.O.; Tekinay A.B. (Royal Society of Chemistry, 2017)

Organizational complexity and functional diversity of the extracellular matrix regulate cellular behaviors. The extracellular matrix is composed of various proteins in the form of proteoglycans, glycoproteins, and nanofibers ...

Incorporating family function into chronic pain disability : the role of catastrophizing

Akbari, F.; Dehghani, M.; Khatibi, A.; Vervoort, T. (Hindawi Publishing Corporation, 2016)

Background: Observers' responses to pain are recently investigated to more comprehensively explain chronic pain (CP) and disability. However, the role of family context, defined as interference in roles, communication, and ...

Relaxation-based viscosity mapping for magnetic particle imaging

Utkur, M.; Muslu, Y.; Saritas, E. U. (Institute of Physics Publishing, 2017)

Magnetic particle imaging (MPI) has been shown to provide remarkable contrast for imaging applications such as angiography, stem cell tracking, and cancer imaging. Recently, there is growing interest in the functional ...

Motion-based nearest vector metric for reference frame selection in the perception of motion

Agaoglu, M. N.; Clarke, A. M.; Herzog, M. H.; Öğmen, H. (Association for Research in Vision and Ophthalmology Inc., 2016)

We investigated how the visual system selects a reference frame for the perception of motion. Two concentric arcs underwent circular motion around the center of the display, where observers fixated. The outer (target) arc's ...

The involvement of centralized and distributed processes in sub-second time interval adaptation : an ERP investigation of apparent motion

Kaya, U.; Yildirim, F. Z.; Kafaligonul, H. (Blackwell Publishing Ltd, 2017)

Accumulating evidence suggests that the timing of brief stationary sounds affects visual motion perception. Recent studies have shown that auditory time interval can alter apparent motion perception not only through ...