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dc.contributor.authorKaroglu, E. T.en_US
dc.contributor.authorHalim, D. O.en_US
dc.contributor.authorErkaya, B.en_US
dc.contributor.authorAltaytas, F.en_US
dc.contributor.authorArslan-Ergul, A.en_US
dc.contributor.authorKonu, O.en_US
dc.contributor.authorAdams, M. M.en_US
dc.date.accessioned2018-04-12T11:10:54Z
dc.date.available2018-04-12T11:10:54Z
dc.date.issued2017-06en_US
dc.identifier.issn0197-4580
dc.identifier.urihttp://hdl.handle.net/11693/37350
dc.description.abstractThe zebrafish has become a popular model for studying normal brain aging due to its large fecundity, conserved genome, and available genetic tools; but little data exists about neurobiological age-related alterations. The current study tested the hypothesis of an association between brain aging and synaptic protein loss across males and females. Western blot analysis of synaptophysin (SYP), a presynaptic vesicle protein, and postsynaptic density-95 (PSD-95) and gephyrin (GEP), excitatory and inhibitory postsynaptic receptor-clustering proteins, respectively, was performed in young, middle-aged, and old male and female zebrafish (Danio rerio) brains. Univariate and multivariate analyses demonstrated that PSD-95 significantly increased in aged females and SYP significantly decreased in males, but GEP was stable. Thus, these key synaptic proteins vary across age in a sexually dimorphic manner, which has been observed in other species, and these consequences may represent selective vulnerabilities for aged males and females. These data expand our knowledge of normal aging in zebrafish, as well as further establish this model as an appropriate one for examining human brain aging.en_US
dc.language.isoEnglishen_US
dc.source.titleNeurobiology of Agingen_US
dc.relation.isversionofhttps://doi.org/10.1016/j.neurobiolaging.2017.02.007en_US
dc.subjectAgingen_US
dc.subjectExcitatory synapsesen_US
dc.subjectGenderen_US
dc.subjectInhibitory synapsesen_US
dc.subjectSynaptic proteinsen_US
dc.subjectZebrafishen_US
dc.subjectBeta tubulinen_US
dc.subjectGephyrinen_US
dc.subjectPostsynaptic density protein 95en_US
dc.subjectSynaptophysinen_US
dc.subjectCarrier proteinen_US
dc.subjectGephyrinen_US
dc.subjectMembrane proteinen_US
dc.subjectSAP90/PSD95 associated proteinen_US
dc.subjectsynaptophysinen_US
dc.subjectAdulten_US
dc.subjectAgeden_US
dc.subjectAnimal tissueen_US
dc.subjectBrain levelen_US
dc.subjectControlled studyen_US
dc.subjectJuvenile animalen_US
dc.subjectNonhumanen_US
dc.subjectProtein analysisen_US
dc.subjectProtein depletionen_US
dc.subjectProtein expressionen_US
dc.subjectProtein functionen_US
dc.subjectProtein localizationen_US
dc.subjectSequence homologyen_US
dc.subjectSex differenceen_US
dc.subjectSynaptic transmissionen_US
dc.subjectWestern blottingen_US
dc.subjectZebra fishen_US
dc.subjectAnalysis of varianceen_US
dc.subjectAnimalen_US
dc.subjectAnimal modelen_US
dc.subjectBrainen_US
dc.subjectGeneticsen_US
dc.subjectHumanen_US
dc.subjectMetabolismen_US
dc.subjectPhysiologyen_US
dc.subjectSexual characteristicsen_US
dc.subjectSynapseen_US
dc.subjectBrainen_US
dc.subjectCarrier Proteinsen_US
dc.subjectSAP90-PSD95 Associated Proteinsen_US
dc.subjectSex Characteristicsen_US
dc.subjectSynapsesen_US
dc.subjectSynaptophysinen_US
dc.titleAging alters the molecular dynamics of synapses in a sexually dimorphic pattern in zebrafish (Danio rerio)en_US
dc.typeArticleen_US
dc.departmentDepartment of Molecular Biology and Genetics
dc.departmentDepartment of Psychology
dc.departmentUNAM - Institute of Materials Science and Nanotechnology
dc.departmentInterdisciplinary Graduate Program in Neuroscience
dc.citation.spage10en_US
dc.citation.epage21en_US
dc.citation.volumeNumber54en_US
dc.identifier.doi10.1016/j.neurobiolaging.2017.02.007en_US
dc.publisherElsevieren_US


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