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dc.contributor.authorGunay, G.en_US
dc.contributor.authorEkiz, M. S.en_US
dc.contributor.authorFerhati, X.en_US
dc.contributor.authorRichichi, B.en_US
dc.contributor.authorNativi, C.en_US
dc.contributor.authorTekinay, A. B.en_US
dc.contributor.authorGuler, M. O.en_US
dc.date.accessioned2018-04-12T11:08:39Z
dc.date.available2018-04-12T11:08:39Z
dc.date.issued2017en_US
dc.identifier.issn1944-8244
dc.identifier.urihttp://hdl.handle.net/11693/37285
dc.description.abstractThe ability of dendritic cells to coordinate innate and adaptive immune responses makes them essential targets for vaccination strategies. Presentation of specific antigens by dendritic cells is required for the activation of the immune system against many pathogens and tumors, and nanoscale materials can be functionalized for active targeting of dendritic cells. In this work, we integrated an immunogenic, carbohydrate melanoma-associated antigen-mimetic GM3-lactone molecule into mannosylated peptide amphiphile nanofibers to target dendritic cells through DC-SIGN receptor. Based on morphological and functional analyses, when dendritic cells were treated with peptide nanofiber carriers, they showed significant increase in antigen internalization and a corresponding increase in the surface expression of the activation and maturation markers CD86, CD83 and HLA-DR, in addition to exhibiting a general morphology consistent with dendritic cell maturation. These results indicate that mannosylated peptide amphiphile nanofiber carriers are promising candidates to target dendritic cells for antigen delivery. © 2017 American Chemical Society.en_US
dc.language.isoEnglishen_US
dc.source.titleACS Applied Materials and Interfacesen_US
dc.relation.isversionofhttp://dx.doi.org/10.1021/acsami.7b04094en_US
dc.subjectCancer antigensen_US
dc.subjectCarbohydrate melanoma associated antigenen_US
dc.subjectDendritic cellsen_US
dc.subjectAmphiphilesen_US
dc.subjectAntigensen_US
dc.subjectBiomimeticsen_US
dc.subjectCarbohydratesen_US
dc.subjectChemical activationen_US
dc.subjectCytologyen_US
dc.subjectDermatologyen_US
dc.subjectDiseasesen_US
dc.subjectEstersen_US
dc.subjectImmune systemen_US
dc.subjectMoleculesen_US
dc.subjectNanofibersen_US
dc.subjectOncologyen_US
dc.subjectPeptidesen_US
dc.subjectPolypeptidesen_US
dc.subjectAdaptive immune responseen_US
dc.subjectAntigen deliveryen_US
dc.subjectCancer immunotherapyen_US
dc.subjectDendritic cellsen_US
dc.subjectNano-scale materialsen_US
dc.subjectPeptide amphiphilesen_US
dc.subjectSurface expressionen_US
dc.subjectVaccination strategyen_US
dc.subjectCellsen_US
dc.titleAntigenic GM3 lactone mimetic molecule integrated mannosylated glycopeptide nanofibers for the activation and maturation of dendritic cellsen_US
dc.typeArticleen_US
dc.departmentNeuroscience Graduate Program
dc.departmentUNAM - Institute of Materials Science and Nanotechnology
dc.citation.spage16035en_US
dc.citation.epage16042en_US
dc.citation.volumeNumber9en_US
dc.citation.issueNumber19en_US
dc.identifier.doi10.1021/acsami.7b04094en_US
dc.publisherAmerican Chemical Societyen_US


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