Singlet oxygen generation with chemical excitation of an erythrosine-luminol conjugate

Date
2017
Authors
Yesilgul, N.
Uyar, T. B.
Seven, O.
Akkaya, E. U.
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Source Title
ACS Omega
Print ISSN
2470-1343
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American Chemical Society
Volume
2
Issue
4
Pages
1367 - 1371
Language
English
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Abstract

Chemical generation of singlet oxygen under biologically relevant conditions is very important, considering the role played by singlet oxygen in cancer therapeutics. We now demonstrate that a luminol derivative can be chemically excited and transfer the excitation energy to the covalently attached photosensitizer derived from erythrosin. A photosensitizer module, when excited in this manner, can generate singlet oxygen in solution. As hydrogen peroxide is present in a relatively high concentration in cancer cells, singlet oxygen generation through chemical excitation may evolve into an important therapeutic approach.

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Published Version (Please cite this version)