Equipping mesh nodes with multiple radios that support multiple wireless channels is considered a promising solution to overcome the capacity limitation of single-radio wireless mesh networks. However, careful and intelligent radio resource management is needed to take full advantage of the extra radios on the mesh nodes. Flow-radio assignment and channel assignment procedures should obey the physical constraints imposed by the radios as well as the topological constraints imposed by routing. Varying numbers of wireless channels are available for the channel assignment procedure for different wireless communication standards. To further complicate the problem, the wireless communication standard implemented by the radios of the wireless mesh network may define overlapping as well as orthogonal channels, as in the case of the IEEE 802.11b/g family of standards. This paper presents Distributed Flow-Radio Channel Assignment, a distributed joint flow-radio and channel assignment scheme and the accompanying distributed protocol in the context of multi-channel multi-radio wireless mesh networks. The scheme’s performance is evaluated on small networks for which the optimal flow-radio and channel configuration can be computed, as well as on large random topologies.