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    Probing viscosity via relaxation in magnetic particle imaging

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    Date Issued
    2017-01
    Author
    Ütkür, Mustafa
    Embargo Release Date
    2018-01-25
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    Please cite this item using this persistent URL
    http://hdl.handle.net/11693/32620
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    • Dept. of Electrical and Electronics Engineering - Master's degree [511]
    Advisor
    Sarıtaş, Emine Ülkü
    Publisher
    Bilkent University
    Abstract
    Magnetic Particle Imaging (MPI) is a high-contrast imaging modality with applications such as angiography, stem cell tracking, and cancer imaging. In recent years, MPI was shown to be a potential functional imaging modality through \color MPI" techniques, where responses from different nanoparticles can be distinguished. These techniques can be extended to differentiate environmental conditions or states such as different viscosities. Increased viscosity in vivo was shown to be related with various diseases such as hypertension, atherosclerosis, and cancer. Through color MPI techniques, MPI shows a great promise for mapping viscosity and for helping in the diagnosis of these important diseases. This thesis demonstrates the capability of MPI to map viscosities through an estimation of relaxation time constant of nanoparticles. This capability is verified through an extensive experimental work with a magnetic particle spectrometer (MPS) setup that is custom designed. These experiments are conducted for the biologically important viscosity range between 0.89 mPa.s and 15.33 mPa.s, at four different frequencies (between 250 Hz and 10.8 kHz) and at three different field amplitudes (between 5 mT and 15 mT). The results demonstrate MPI's viscosity mapping capability in a biological range.

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    BİLKENT UNIVERSITY

    Copyright © Bilkent University - Library Technical Services | 06800 Bilkent, Ankara TURKEY
    If you have trouble accessing this page and need to request an alternate format, contact the webmaster. Phone: (312) 290 1771

    Contact Us | Send Feedback | Off-Campus Access