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dc.contributor.advisorİder, Y. Ziya
dc.contributor.authorGürler, Necip
dc.date.accessioned2016-09-27T10:51:45Z
dc.date.available2016-09-27T10:51:45Z
dc.date.copyright2016-09
dc.date.issued2016-09
dc.date.submitted2016-09-26
dc.identifier.urihttp://hdl.handle.net/11693/32292
dc.descriptionCataloged from PDF version of article.en_US
dc.descriptionThesis (Ph. D.): Bilkent University, Department of Electrical and Electronics Engineering, İhsan Doğramacı Bilkent University, 2016.en_US
dc.descriptionIncludes bibliographical references (leaves 102-111).en_US
dc.description.abstractImaging of electrical properties (EPs, i.e. conductivity and dielectric permittivity) of tissues give valuable information about the physiological and pathological conditions of tissues. Among the EP imaging modalities, magnetic resonance electrical properties tomography (MREPT) has the potential that it can be used both in clinical diagnosis and local specific absorption rate (SAR) calculation. However, there are several issues in the conventional MREPT methods such as boundary artifact, low convective field (LCF) artifact, transceive phase assumption (TPA), usability of only birdcage coil, which precludes the clinical applicability of these methods. This dissertation aims that MREPT can be used in the clinical applications in a fast and reliable way by solving these issues in the conventional MREPT methods. For this purpose two novel methods have been proposed. One is the receive sensitivity (Bequation (PDE) is in the form of convection-reaction equation the coeffcients of which are the derivatives of the measured MR transceive phase. Since only MR phase is used, the method is considerably fast (no B1 mapping is required), and it is applicable for any coil configuration (no TPA is used). The superiority of the proposed method over the conventional phase based EPT method has been shown both in the simple phantom simulations and experiments and in the noisy human brain simulation and healthy volunteer experiments. Furthermore, initial clinical trials with two patients with neurovascular diseases in the subacute phase have been conducted. Each examination took about six minutes. It has been observed that the conductivity increases in the ischemic region when compared to other regions, whereas no conductivity change has been observed in the hematoma region. To standardize the method for the specific clinical applications such as differentiation of the ischemic stroke from the hemorrhagic stroke in the acute phase, further case studies need to be conducted in a systematic way.en_US
dc.description.statementofresponsibilityby Necip Gürler.en_US
dc.format.extentxx, 113 leaves : illustrations, charts (some color)en_US
dc.language.isoEnglishen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectMagnetic resonance electrical properties tomography (MREPT)en_US
dc.subjectConvection reaction equation based MREPT (cr-MREPT)en_US
dc.subjectPhase based EPTen_US
dc.subjectElectrical property imagingen_US
dc.subjectConductivity imagingen_US
dc.subjectMultichannel electrical property imagingen_US
dc.titleMultichannel and phase based magnetic resonance electrical properties tomographyen_US
dc.title.alternativeÇok kanallı ve faz temelli manyetik rezonans elektriksel özellik tomografisien_US
dc.typeThesisen_US
dc.departmentDepartment of Electrical and Electronics Engineeringen_US
dc.publisherBilkent Universityen_US
dc.description.degreePh.D.en_US
dc.identifier.itemidB154093


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