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dc.contributor.advisorGüler, Mustafa Özgüren_US
dc.contributor.authorZengin, Aygülen_US
dc.date.accessioned2016-04-26T12:40:36Z
dc.date.available2016-04-26T12:40:36Z
dc.date.copyright2016-02
dc.date.issued2016-02
dc.date.submitted02-03-2016
dc.identifier.urihttp://hdl.handle.net/11693/28986
dc.descriptionCataloged from PDF version of thesis.en_US
dc.descriptionIncludes bibliographical references (leaves 67-76).en_US
dc.descriptionThesis (M.S.): Bilkent University, Materials Science and Nanotechnology Program, İhsan Doğramacı Bilkent University, 2016.en_US
dc.description.abstractThe self-assembled peptide nano ber gels have received enormous attention because of their inherent biocompatible, biodegradable and functional properties. They provide a smart platform for a range of applications such as tissue engineering, drug delivery and wound healing. These gels are formed through noncovalent interactions such as hydrogen bonding, hydrophobic interactions and electrostatic interactions among the peptide amphiphile molecules at physiological conditions. In order to understand the stability of these gels in the presence of proteases in natural conditions, we studied degradation behavior of the gels with proteinase K, which is a non-speci c protease cleaving the peptide bonds. Degradation process was studied by measuring weight measurement and TEM imaging. In addition, sustained release of Rhodamine B from these gels was also studied in the presence of proteases. The results clearly demonstrated that presence of D- amino acids in the peptide nano ber network signi cantly improves their stability against enzymatic degradation and change the release pro le of the encapsulated molecules in the gels. These ndings are interesting for biomedical applications of these materials due to their tunable degradation and controlled release behavior.en_US
dc.description.statementofresponsibilityby Aygül Zengin.en_US
dc.format.extentxiv, 76 leaves : colour illustrations, charts.en_US
dc.language.isoEnglishen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectPeptide amphiphileen_US
dc.subjectSelf-assemblyen_US
dc.subjectSupramolecular gelen_US
dc.subjectNano beren_US
dc.subjectDamino acidsen_US
dc.subjectControlled releaseen_US
dc.subjectEnzymatic degradationen_US
dc.titleEnzymatic degradation of self-assembled peptide nanofiber gelsen_US
dc.title.alternativeKendiliğinden bir araya gelen peptit nanofiberlerden oluşan jellerin enzimatik degredasyonuen_US
dc.typeThesisen_US
dc.departmentGraduate Program in Materials Science and Nanotechnologyen_US
dc.publisherBilkent Universityen_US
dc.description.degreeM.S.en_US
dc.identifier.itemidB152874
dc.embargo.release2019-03-01


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