Model-based spectral analysis of photon propagation through nanoparticle-labeled epithelial tissues
Author
Cihan, Can
Arifler, D.
Date
2011Source Title
Proceedings of SPIE, Progress in Biomedical Optics and Imaging
Print ISSN
1605-7422
Publisher
SPIE
Volume
8087
Language
English
Type
Conference PaperItem Usage Stats
153
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96
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Abstract
Metal nanoparticles can function as optical contrast enhancers for reflectance-based diagnosis of epithelial precancer. We carry out Monte Carlo simulations to model photon propagation through normal tissues, unlabeled precancerous tissues, and precancerous tissues labeled with gold nanospheres and we compute the spectral reflectance response of these different tissue states. The results indicate that nanoparticle-induced changes in the spectral reflectance profile of tissues depend not only on the properties of these particles but also on the source-detector geometry used. When the source and detector fibers are oriented side by side and perpendicular to the tissue surface, the reflectance intensity of precancerous tissue is lower compared to that of normal tissue over the entire wavelength range simulated and addition of nanospheres enhances this negative contrast. When the fibers are tilted toward each other, the reflectance intensity of precancerous tissue is higher compared to that of normal tissue and labeling with nanospheres causes a significant enhancement of this positive contrast. The results also suggest that model-based spectral analysis of photon propagation through nanoparticle-labeled tissues provides a useful framework to quantify the extent of achievable contrast enhancement due to external labeling and to assess the diagnostic potential of nanoparticle-enhanced optical measurements. © 2011 SPIE-OSA.
Keywords
Epithelial precancerMonte Carlo modeling
Nanoparticles
Optical spectroscopy
Photon propagation
Reflectance
Contrast Enhancement
Diagnostic potential
Epithelial precancer
Epithelial tissue
Gold nanospheres
Metal nanoparticles
Monte Carlo modeling
Monte Carlo Simulation
Normal tissue
Optical contrast
Optical measurement
Optical spectroscopy
Photon propagation
Spectral reflectances
Tissue surface
Wavelength ranges
Computer simulation
Histology
Monte Carlo methods
Nanoparticles
Nanospheres
Optical data processing
Photons
Reflection
Spectroscopy
Spectrum analysis
Tissue
Permalink
http://hdl.handle.net/11693/28380Published Version (Please cite this version)
http://dx.doi.org/10.1117/12.889421Collections
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