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      Model-based spectral analysis of photon propagation through nanoparticle-labeled epithelial tissues

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      Author
      Cihan, Can
      Arifler, D.
      Date
      2011
      Source Title
      Proceedings of SPIE, Progress in Biomedical Optics and Imaging
      Print ISSN
      1605-7422
      Publisher
      SPIE
      Volume
      8087
      Language
      English
      Type
      Conference Paper
      Item Usage Stats
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      Abstract
      Metal nanoparticles can function as optical contrast enhancers for reflectance-based diagnosis of epithelial precancer. We carry out Monte Carlo simulations to model photon propagation through normal tissues, unlabeled precancerous tissues, and precancerous tissues labeled with gold nanospheres and we compute the spectral reflectance response of these different tissue states. The results indicate that nanoparticle-induced changes in the spectral reflectance profile of tissues depend not only on the properties of these particles but also on the source-detector geometry used. When the source and detector fibers are oriented side by side and perpendicular to the tissue surface, the reflectance intensity of precancerous tissue is lower compared to that of normal tissue over the entire wavelength range simulated and addition of nanospheres enhances this negative contrast. When the fibers are tilted toward each other, the reflectance intensity of precancerous tissue is higher compared to that of normal tissue and labeling with nanospheres causes a significant enhancement of this positive contrast. The results also suggest that model-based spectral analysis of photon propagation through nanoparticle-labeled tissues provides a useful framework to quantify the extent of achievable contrast enhancement due to external labeling and to assess the diagnostic potential of nanoparticle-enhanced optical measurements. © 2011 SPIE-OSA.
      Keywords
      Epithelial precancer
      Monte Carlo modeling
      Nanoparticles
      Optical spectroscopy
      Photon propagation
      Reflectance
      Contrast Enhancement
      Diagnostic potential
      Epithelial precancer
      Epithelial tissue
      Gold nanospheres
      Metal nanoparticles
      Monte Carlo modeling
      Monte Carlo Simulation
      Normal tissue
      Optical contrast
      Optical measurement
      Optical spectroscopy
      Photon propagation
      Spectral reflectances
      Tissue surface
      Wavelength ranges
      Computer simulation
      Histology
      Monte Carlo methods
      Nanoparticles
      Nanospheres
      Optical data processing
      Photons
      Reflection
      Spectroscopy
      Spectrum analysis
      Tissue
      Permalink
      http://hdl.handle.net/11693/28380
      Published Version (Please cite this version)
      http://dx.doi.org/10.1117/12.889421
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      • Department of Electrical and Electronics Engineering 3524
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