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dc.contributor.authorTekdaş, D. A.en_US
dc.contributor.authorGarifullin, R.en_US
dc.contributor.authorŞentürk, B.en_US
dc.contributor.authorZorlu, Y.en_US
dc.contributor.authorGundogdu, U.en_US
dc.contributor.authorAtalar, E.en_US
dc.contributor.authorTekinay, A. B.en_US
dc.contributor.authorChernonosov, A. A.en_US
dc.contributor.authorYerli, Y.en_US
dc.contributor.authorDumoulin, F.en_US
dc.contributor.authorGuler, M. O.en_US
dc.contributor.authorAhsen, V.en_US
dc.contributor.authorGürek, A. G.en_US
dc.date.accessioned2016-02-08T10:59:01Z
dc.date.available2016-02-08T10:59:01Z
dc.date.issued2014en_US
dc.identifier.issn0031-8655
dc.identifier.urihttp://hdl.handle.net/11693/26379
dc.description.abstractThe design and synthesis of a phthalocyanine - Gd-DOTA conjugate is presented to open the way to novel molecular theranostics, combining the properties of MRI contrast imaging with photodynamic therapy. The rational design of the conjugate integrates isomeric purity of the phthalocyanine core substitution, suitable biocompatibility with the use of polyoxo water-solubilizing substituents, and a convergent synthetic strategy ended by the use of click chemistry to graft the Gd-DOTA moiety to the phthalocyanine. Photophysical and photochemical properties, contrast imaging experiments and preliminary in vitro investigations proved that such a combination is relevant and lead to a new type of potential theranostic agent.en_US
dc.language.isoEnglishen_US
dc.source.titlePhotochemistry and Photobiologyen_US
dc.relation.isversionofhttp://dx.doi.org/10.1111/php.12332en_US
dc.subjectBiomaterialen_US
dc.subjectContrast mediumen_US
dc.subjectHeterocyclic compounden_US
dc.subjectIndole derivativeen_US
dc.subjectOrganometallic compounden_US
dc.subjectPhotosensitizing agenten_US
dc.subjectPhthalocyanineen_US
dc.subjectChemistryen_US
dc.subjectElectrospray mass spectrometryen_US
dc.subjectHumanen_US
dc.subjectNuclear magnetic resonance imagingen_US
dc.subjectNuclear magnetic resonance spectroscopyen_US
dc.subjectProceduresen_US
dc.subjectBiocompatible materialsen_US
dc.subjectContrast mediaen_US
dc.subjectIndolesen_US
dc.subjectMagnetic resonance imagingen_US
dc.subjectMagnetic resonance spectroscopyen_US
dc.subjectMCF-7 cellsen_US
dc.titleDesign of a Gd-DOTA-phthalocyanine conjugate combining MRI contrast imaging and photosensitization properties as a potential molecular theranosticen_US
dc.typeArticleen_US
dc.departmentDepartment of Electrical and Electronics Engineering
dc.departmentInstitute of Materials Science and Nanotechnologyen_US
dc.departmentNanotechnology Research Centeren_US
dc.departmentNational Magnetic Resonance Research Centeren_US
dc.citation.spage1376en_US
dc.citation.epage1386en_US
dc.citation.volumeNumber90en_US
dc.citation.issueNumber6en_US
dc.identifier.doi10.1111/php.12332en_US
dc.publisherWiley-Blackwell Publishing, Inc.en_US


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