Smad2 and Smad4 gene mutations in hepatocellular carcinoma

Date
1999
Authors
Yakicier, M. C.
Irmak, M. B.
Romano, A.
Kew, M.
Ozturk, M.
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Source Title
Oncogene
Print ISSN
0950-9232
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Volume
18
Issue
34
Pages
4879 - 4883
Language
English
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Abstract

TGF-β is a negative regulator of liver growth. Smad family of genes, as mediators of TGF-β pathway, are candidate tumor suppressor genes in hepatocellular carcinoma (HCC). We studied 35 HCC and non-tumour liver tissues for possible mutations in Smad2 and Smad4 genes. Three tumours displayed somatic mutations; two in Smad4 (Asp332Gly and Cys401Arg) and one in Smad2 (Gln407Arg) genes. All three mutations were A:T → G:C transitions suspected to result from oxidative stress as observed in mitochondrial DNA. These observation demonstrate that TGF-β pathway is altered in hepatocellular carcinoma.

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Published Version (Please cite this version)