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      Comparative evaluation of in vitro cytotoxic effects among parent abietyl alcohol and novel fatty acid ester derivatives against MCF7 and hepatocellular carcinoma cell lines

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      Author(s)
      Mustufa, Muhammad Ayaz
      Aslam, A.
      Özen, Çiğdem
      Hashmi, I. A.
      Naqvi, N.
      Öztürk, Mehmet
      Ali, F. I.
      Date
      2014
      Source Title
      Pakistan Journal of Pharmaceutical Sciences
      Print ISSN
      1011-601X
      Publisher
      Pakistan Journal of Pharmaceutical Sciences
      Volume
      27
      Issue
      6
      Pages
      2013 - 2018
      Language
      English
      Type
      Article
      Item Usage Stats
      227
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      127
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      Abstract
      Synthesis of twelve hitherto unreported esters of abietyl alcohol and screening of these esters against four cancer cell lines including one breast cancer line MCF7 and four hepatocellular carcinoma cell lines (HCC) Huh7, Hep3B, Snu449 and Plc has been determined using SRB assay. The Cell cycle progression showed changes in cellular behaviour after 48 and 72 hours in MCF7 and Huh7 cell lines. Abietyl alcohol was obtained from the reduction of abietic acid, a tricyclic diterpene, isolated from oleoresin of Pinus longifolia Roxberghii.
      Keywords
      Abietic acid
      Cancer cell lines
      Diterpene
      SRB assay
      Steglich esterification
      Permalink
      http://hdl.handle.net/11693/25013
      Collections
      • Department of Molecular Biology and Genetics 512
      • Genetics and Biotechnology Research Center (BİLGEN) 16
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