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dc.contributor.authorYesildal, F.en_US
dc.contributor.authorAydin, F. N.en_US
dc.contributor.authorDeveci, S.en_US
dc.contributor.authorTekin, S.en_US
dc.contributor.authorAydin, I.en_US
dc.contributor.authorMammadov R.en_US
dc.contributor.authorFermanli, O.en_US
dc.contributor.authorAvcu, F.en_US
dc.contributor.authorAcikel, C. H.en_US
dc.contributor.authorOzgurtas, T.en_US
dc.date.accessioned2016-02-08T10:26:20Z
dc.date.available2016-02-08T10:26:20Z
dc.date.issued2015en_US
dc.identifier.issn0960-3271
dc.identifier.urihttp://hdl.handle.net/11693/24247
dc.description.abstractAngiogenesis is the process of generating new blood vessels from preexisting vessels and is considered essential in many pathological conditions. The purpose of the present study is to evaluate the effect of aspartame on angiogenesis in vivo chick chorioallantoic membrane (CAM) and wound-healing models as well as in vitro 2,3-bis-2H-tetrazolium-5-carboxanilide (XTT) and tube formation assays. In CAM assay, aspartame increased angiogenesis in a concentration-dependent manner. Compared with the control group, aspartame has significantly increased vessel proliferation (p < 0.001). In addition, in vivo rat model of skin wound-healing study showed that aspartame group had better healing than control group, and this was statistically significant at p < 0.05. There was a slight proliferative effect of aspartame on human umbilical vein endothelial cells on XTT assay in vitro, but it was not statistically significant; and there was no antiangiogenic effect of aspartame on tube formation assay in vitro. These results provide evidence that aspartame induces angiogenesis in vitro and in vivo; so regular use may have undesirable effect on susceptible cases. © The Author(s) 2015.en_US
dc.language.isoEnglishen_US
dc.source.titleHuman and Experimental Toxicologyen_US
dc.relation.isversionofhttps://doi.org/10.1177/0960327114537535en_US
dc.subjectAngiogenesisen_US
dc.subjectAspartameen_US
dc.subjectCAM assayen_US
dc.subjectSkin wound healingen_US
dc.subjectTube formationen_US
dc.titleAspartame induces angiogenesis in vitro and in vivo modelsen_US
dc.typeArticleen_US
dc.departmentNanotechnology Research Center (NANOTAM)en_US
dc.citation.spage260en_US
dc.citation.epage265en_US
dc.citation.volumeNumber34en_US
dc.citation.issueNumber3en_US
dc.identifier.doi10.1177/0960327114537535en_US
dc.publisherSAGE Publications Ltden_US


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