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dc.contributor.authorOzturk, N.en_US
dc.contributor.authorErdal, E.en_US
dc.contributor.authorMumcuoglu, M.en_US
dc.contributor.authorAkcali, K. C.en_US
dc.contributor.authorYalcin, O.en_US
dc.contributor.authorSenturk, S.en_US
dc.contributor.authorArslan-Ergul, A.en_US
dc.contributor.authorGur, B.en_US
dc.contributor.authorYulug, I.en_US
dc.contributor.authorCetin Atalay, R.en_US
dc.contributor.authorYakicier, C.en_US
dc.contributor.authorYagci, T.en_US
dc.contributor.authorTez, M.en_US
dc.contributor.authorOzturk, M.en_US
dc.date.accessioned2016-02-08T10:20:15Z
dc.date.available2016-02-08T10:20:15Z
dc.date.issued2006en_US
dc.identifier.issn0027-8424
dc.identifier.urihttp://hdl.handle.net/11693/23851
dc.description.abstractTumor cells have the capacity to proliferate indefinitely that is qualified as replicative immortality. This ability contrasts with the intrinsic control of the number of cell divisions in human somatic tissues by a mechanism called replicative senescence. Replicative immortality is acquired by inactivation of p53 and p16INK4a genes and reactivation of hTERT gene expression. It is unknown whether the cancer cell replicative immortality is reversible. Here, we show the spontaneous induction of replicative senescence in p53-and p16 INK4a-deficient hepatocellular carcinoma cells. This phenomenon is characterized with hTERT repression, telomere shortening, senescence arrest, and tumor suppression. SIP1 gene (ZFHX1B) is partly responsible for replicative senescence, because short hairpin RNA-mediated SIP1 inactivation released hTERT repression and rescued clonal hepatocellular carcinoma cells from senescence arrest. © 2006 by The National Academy of Sciences of the USA.en_US
dc.language.isoEnglishen_US
dc.source.titleProceedings of the National Academy of Sciences of the United States of Americaen_US
dc.relation.isversionofhttp://dx.doi.org/10.1073/pnas.0510877103en_US
dc.subjectImmortalityen_US
dc.subjectLiver canceren_US
dc.subjectp53en_US
dc.subjectSIP1en_US
dc.subjectTelomeraseen_US
dc.subjectProtein p16INK4aen_US
dc.subjectRNAen_US
dc.titleReprogramming of replicative senescence in hepatocellular carcinoma-derived cellsen_US
dc.typeArticleen_US
dc.departmentDepartment of Molecular Biology and Geneticsen_US
dc.citation.spage2178en_US
dc.citation.epage2183en_US
dc.citation.volumeNumber103en_US
dc.citation.issueNumber7en_US
dc.identifier.doi10.1073/pnas.0510877103en_US
dc.publisherNational Academy of Sciencesen_US


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