Sulfatide and its synthetic analogues recognition by Moraxella catarrhalis

Date
2006
Authors
Ozcelik, P.
Bezirci, F. B.
Suzuki, Y.
Uzawa, H.
Nishida, Y.
Kobayashi, K.
Suzuki, T.
Miyamoto, D.
Nagatake, T.
Ahmed, K.
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Source Title
Microbiology and Immunology
Print ISSN
0385-5600
Electronic ISSN
Publisher
Springer
Volume
50
Issue
12
Pages
967 - 970
Language
English
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Abstract

Moraxella catarrhalis is one of the major pathogens of respiratory and middle ear infections. Attachment of this bacterium to the surface of human pharyngeal epithelial cells is the first step in the pathogenesis of infections. This study revealed that sulfatide might act as a binding molecule for the attachment of M. catarrhalis to human pharyngeal epithelial cells. Furthermore, six different synthetic sulfatides were found to inhibit the attachment of M. catarrhalis significantly at an optimum concentration of 10 μg/ml. Synthetic sulfatides may have the potential to be used as a therapy to prevent M. catarrhalis infections.

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