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dc.contributor.authorHatirnaz, O.en_US
dc.contributor.authorUre, U.en_US
dc.contributor.authorAr, C.en_US
dc.contributor.authorAkyerli, C.en_US
dc.contributor.authorSoysal, T.en_US
dc.contributor.authorFerhanoǧlu, B.en_US
dc.contributor.authorÖzçelik, T.en_US
dc.contributor.authorOzbek, U.en_US
dc.date.accessioned2016-02-08T10:13:35Z
dc.date.available2016-02-08T10:13:35Z
dc.date.issued2007en_US
dc.identifier.issn0361-8609
dc.identifier.urihttp://hdl.handle.net/11693/23413
dc.description.abstractSOCS-1, an important protein in the JAK/STAT pathway, has a role in the down stream of BCR-ABL protein kinase. We investigated 56 CML patients and 16 controls for the methylation status of SOCS-1 gene promoter and Exon 2 regions. Exon 2 was found to be methylated in 58.9% of the patients and 93.8% of the controls [P = 0.020, OR = 0.121(0.015-0.957)%95CI]. The promoter region was found unmethylated in all patient samples and controls. Although previous studies revealed a relation between SOCS1 gene Exon-2 hypermethylation and CML development or progression, the results of this study showed no such correlation. On the contrary, our results might be indicating hypomethylation in CML patients, this hypothesis need to be studied in larger study population.en_US
dc.language.isoEnglishen_US
dc.source.titleAmerican Journal of Hematologyen_US
dc.relation.isversionofhttp://dx.doi.org/10.1002/ajh.20886en_US
dc.subjectBCR ABL proteinen_US
dc.subjectJanus kinaseen_US
dc.subjectSTAT proteinen_US
dc.subjectsuppressor of cytokine signaling 1en_US
dc.subjectArticleen_US
dc.subjectCancer growthen_US
dc.subjectCancer patienten_US
dc.subjectChronic myeloid leukemiaen_US
dc.subjectControlled studyen_US
dc.subjectDNA methylationen_US
dc.subjectExonen_US
dc.subjectGeneen_US
dc.subjectHumanen_US
dc.subjectLeukemogenesisen_US
dc.subjectMajor clinical studyen_US
dc.subjectMaleen_US
dc.subjectPriority journalen_US
dc.subjectPromoter regionen_US
dc.subjectProtein protein interactionen_US
dc.subjectSOCS 1 geneen_US
dc.subjectAdulten_US
dc.subjectDNA Methylationen_US
dc.subjectExonsen_US
dc.subjectFemaleen_US
dc.subjectHumansen_US
dc.subjectLeukemia, Myeloid, Chronicen_US
dc.subjectMaleen_US
dc.subjectMiddle Ageden_US
dc.subjectSuppressor of Cytokine Signaling Proteinsen_US
dc.titleThe SOCS-1 gene methylation in chronic myeloid leukemia patientsen_US
dc.typeArticleen_US
dc.departmentDepartment of Molecular Biology and Geneticsen_US
dc.citation.spage729en_US
dc.citation.epage730en_US
dc.citation.volumeNumber82en_US
dc.citation.issueNumber8en_US
dc.identifier.doi10.1002/ajh.20886en_US
dc.publisherJohn Wiley & Sons, Inc.en_US


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