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      Thinking outside the silicon box: molecular and logic as an additional layer of selectivity in singlet oxygen generation for photodynamic therapy

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      Author
      Ozlem, S.
      Akkaya, E. U.
      Date
      2009
      Source Title
      Journal of the American Chemical Society
      Print ISSN
      0002-7863
      Volume
      131
      Issue
      1
      Pages
      48 - 49
      Language
      English
      Type
      Article
      Item Usage Stats
      114
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      Abstract
      A simple derivative of a well-known dye bodipy appears to be a satisfactory sensitizer for singlet oxygen. Moreover, the rate of singlet oxygen generation can be modulated by two cancer-related cellular parameters, sodium ion concentration and acidity. Singlet oxygen generation rate is maximal when sodium ions and an organic acid were added. The operation of this molecular automaton follows AND logic, which introduces an additional layer of selectivity in the photodynamic action of the reagent. It should also be noted that in this system sensing, computing and actuating functions are realized within a single molecule. Copyright © 2008 American Chemical Society.
      Keywords
      Cellular parameters
      Photodynamic action
      Single molecule
      Singlet oxygen
      Singlet oxygen generation
      Sodium ion concentration
      Sodium ions
      Gas generators
      Metal ions
      Organic acids
      Photodynamic therapy
      Molecular oxygen
      Permalink
      http://hdl.handle.net/11693/22855
      Published Version (Please cite this version)
      http://dx.doi.org/10.1021/ja808389t
      Collections
      • Department of Chemistry 637
      • Institute of Materials Science and Nanotechnology (UNAM) 1904
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