Thinking outside the silicon box: molecular and logic as an additional layer of selectivity in singlet oxygen generation for photodynamic therapy
Author
Ozlem, S.
Akkaya, E. U.
Date
2009Source Title
Journal of the American Chemical Society
Print ISSN
0002-7863
Volume
131
Issue
1
Pages
48 - 49
Language
English
Type
ArticleItem Usage Stats
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Abstract
A simple derivative of a well-known dye bodipy appears to be a satisfactory sensitizer for singlet oxygen. Moreover, the rate of singlet oxygen generation can be modulated by two cancer-related cellular parameters, sodium ion concentration and acidity. Singlet oxygen generation rate is maximal when sodium ions and an organic acid were added. The operation of this molecular automaton follows AND logic, which introduces an additional layer of selectivity in the photodynamic action of the reagent. It should also be noted that in this system sensing, computing and actuating functions are realized within a single molecule. Copyright © 2008 American Chemical Society.
Keywords
Cellular parametersPhotodynamic action
Single molecule
Singlet oxygen
Singlet oxygen generation
Sodium ion concentration
Sodium ions
Gas generators
Metal ions
Organic acids
Photodynamic therapy
Molecular oxygen