Synthesis of novel substituted purine derivatives and identification of the cell death mechanism
Date
2015Source Title
European Journal of Medicinal Chemistry
Print ISSN
2235234
Publisher
Elsevier Masson SAS
Volume
89
Pages
701 - 720
Language
English
Type
ArticleItem Usage Stats
105
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views
149
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downloads
Abstract
Novel substituted adenine and purine derivatives were designed and synthesized.Compound 36 displayed the greatest cytotoxic activity with IC50 less than 1 1/4M.36 induces senescence associated cell death, which was demonstrated with SA2-Gal assay. © 2014 Elsevier Masson SAS.
Keywords
AdenineCytotoxic activity
Hepatocellular carcinoma
Purine derivatives
Senescence
antineoplastic agent
purine
purine derivative
cell death
cell proliferation
chemical structure
chemistry
dose response
drug effects
drug screening
HCT116 cell line
HepG2 cell line
human
structure activity relation
synthesis
tumor cell culture
Antineoplastic Agents
Cell Death
Cell Proliferation
Dose-Response Relationship, Drug
Drug Screening Assays, Antitumor
HCT116 Cells
Hep G2 Cells
Humans
Models, Molecular
Molecular Structure
Purines
Structure-Activity Relationship
Tumor Cells, Cultured