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      • Faculty of Science
      • Department of Molecular Biology and Genetics
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      Synthesis of novel substituted purine derivatives and identification of the cell death mechanism

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      Author
      Demir, Z.
      Guven, E.B.
      Ozbey, S.
      Kazak, C.
      Atalay, R.C.
      Tuncbilek, M.
      Date
      2015
      Source Title
      European Journal of Medicinal Chemistry
      Print ISSN
      2235234
      Publisher
      Elsevier Masson SAS
      Volume
      89
      Pages
      701 - 720
      Language
      English
      Type
      Article
      Item Usage Stats
      105
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      149
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      Abstract
      Novel substituted adenine and purine derivatives were designed and synthesized.Compound 36 displayed the greatest cytotoxic activity with IC50 less than 1 1/4M.36 induces senescence associated cell death, which was demonstrated with SA2-Gal assay. © 2014 Elsevier Masson SAS.
      Keywords
      Adenine
      Cytotoxic activity
      Hepatocellular carcinoma
      Purine derivatives
      Senescence
      antineoplastic agent
      purine
      purine derivative
      cell death
      cell proliferation
      chemical structure
      chemistry
      dose response
      drug effects
      drug screening
      HCT116 cell line
      HepG2 cell line
      human
      structure activity relation
      synthesis
      tumor cell culture
      Antineoplastic Agents
      Cell Death
      Cell Proliferation
      Dose-Response Relationship, Drug
      Drug Screening Assays, Antitumor
      HCT116 Cells
      Hep G2 Cells
      Humans
      Models, Molecular
      Molecular Structure
      Purines
      Structure-Activity Relationship
      Tumor Cells, Cultured
      Permalink
      http://hdl.handle.net/11693/22691
      Published Version (Please cite this version)
      http://dx.doi.org/10.1016/j.ejmech.2014.10.080
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