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dc.contributor.authorArsava, E. M.en_US
dc.contributor.authorBas, D. F.en_US
dc.contributor.authorAtalar, E.en_US
dc.contributor.authorHas, A. C.en_US
dc.contributor.authorOguz, K. K.en_US
dc.contributor.authorTopcuoglu, M. A.en_US
dc.date.accessioned2016-02-08T09:58:56Z
dc.date.available2016-02-08T09:58:56Z
dc.date.issued2015en_US
dc.identifier.issn0039-2499
dc.identifier.urihttp://hdl.handle.net/11693/22347
dc.description.abstractBackground and Purpose: The widespread use of ambulatory cardiac monitoring has not only increased the detection of high-risk arrhythmias like persistent and paroxysmal atrial fibrillation (AF), but also made it possible to identify other aberrations such as short-lasting (<30 seconds) irregular runs of supraventricular tachycardia. Ischemic stroke phenotype might be helpful in understanding whether these nonsustained episodes play a similar role in stroke pathophysiology like their persistent and paroxysmal counterparts. Methods: In a consecutive series of patients with ischemic stroke, we retrospectively determined clinical and imaging features associated with nonsustained AF (n=126), defined as <30-second-lasting supraventricular tachyarrhythmias with irregular RR interval on 24-hour Holter monitoring, and compared them to patients with persistent/paroxysmal AF (n=239) and no AF (n=246). Results: Patients with persistent/paroxysmal AF significantly differed from patients with nonsustained AF by a higher prevalence of female sex (odds ratio [95% confidence interval], 1.8 [1.1-2.9]), coronary artery disease (1.9 [1.1-3.0]), and embolic imaging features (2.7 [1.1-6.5]), and lower frequency of smoking (0.4 [0.2-0.8]) and hyperlipidemia (0.5 [0.3-0.8]). In contrast, patients with no AF were younger (0.5 [0.4-0.6] per decade) and more likely to be male (1.7 [1.0-2.8]) in comparison with nonsustained AF population. The prevalence of nonsustained AF was similar among cryptogenic and noncryptogenic stroke patients (32% versus 29%). Voxel-wise comparison of lesion probability maps revealed no significant difference between cryptogenic stroke patients with and without nonsustained AF. Conclusions: Clinical features of patients with nonsustained AF exhibited an intermediary phenotype in between patients with persistent/paroxysmal AF and no AF. Furthermore, imaging features did not entirely resemble patterns observed in patients with longer durations of AF.en_US
dc.language.isoEnglishen_US
dc.source.titleStrokeen_US
dc.relation.isversionofhttps://doi.org/10.1161/STROKEAHA.114.006396en_US
dc.subjectAmbulatoryen_US
dc.subjectAtrial fibrillationen_US
dc.subjectElectrocardiographyen_US
dc.subjectMagnetic resonance imagingen_US
dc.subjectAdulten_US
dc.subjectAgeden_US
dc.subjectArticleen_US
dc.subjectAtherosclerosisen_US
dc.subjectAtrial fibrillationen_US
dc.subjectBrain ischemiaen_US
dc.subjectCerebrovascular accidenten_US
dc.subjectCoronary artery diseaseen_US
dc.subjectDiabetes mellitusen_US
dc.subjectFemaleen_US
dc.subjectHolter monitoringen_US
dc.subjectHumanen_US
dc.subjectHyperlipidemiaen_US
dc.subjectHypertensionen_US
dc.subjectMajor clinical studyen_US
dc.subjectMaleen_US
dc.subjectMiddle ageden_US
dc.subjectPersistent atrial fibrillationen_US
dc.subjectPhenotypeen_US
dc.subjectPriority journalen_US
dc.subjectRetrospective studyen_US
dc.subjectRR intervalen_US
dc.subjectSmokingen_US
dc.subjectStroke patienten_US
dc.subjectSupraventricular tachycardiaen_US
dc.subjectTransient ischemic attacken_US
dc.subjectVery elderlyen_US
dc.subjectAtrial fibrillationen_US
dc.subjectBrain ischemiaen_US
dc.subjectElectrocardiographyen_US
dc.subjectPathophysiologyen_US
dc.subjectProbabilityen_US
dc.subjectProceduresen_US
dc.subjectTachycardia, Supraventricularen_US
dc.subjectAgeden_US
dc.subjectAged, 80 and overen_US
dc.subjectAtrial Fibrillationen_US
dc.subjectBrain Ischemiaen_US
dc.subjectElectrocardiography, Ambulatoryen_US
dc.subjectFemaleen_US
dc.subjectHumansen_US
dc.subjectMaleen_US
dc.subjectMiddle Ageden_US
dc.subjectPhenotypeen_US
dc.subjectProbabilityen_US
dc.subjectRetrospective Studiesen_US
dc.subjectStrokeen_US
dc.subjectTachycardiaen_US
dc.subjectSupraventricularen_US
dc.titleIschemic stroke phenotype in patients with nonsustained atrial fibrillationen_US
dc.typeArticleen_US
dc.departmentUMRAM - National Magnetic Resonance Research Centeren_US
dc.citation.spage634en_US
dc.citation.epage640en_US
dc.citation.volumeNumber46en_US
dc.citation.issueNumber3en_US
dc.identifier.doi10.1161/STROKEAHA.114.006396en_US
dc.publisherLippincott Williams and Wilkinsen_US


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