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      A microfluidic based differential plasmon resonance sensor

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      Author
      Okan, M.
      Balci, O.
      Kocabas, C.
      Date
      2011
      Source Title
      Sensors and Actuators, B: Chemical
      Print ISSN
      0925-4005
      Electronic ISSN
      1873-3077
      Publisher
      Elsevier
      Volume
      160
      Issue
      1
      Pages
      670 - 676
      Language
      English
      Type
      Article
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      Abstract
      A new type of differential surface plasmon (SPR) sensor integrated with a microfluidic system is presented. The working principle of the microfluidic device is based on hydrodynamic modulation of two laminar streams inside a microchannel to provide periodic changes of the environment on the SPR sensor. The modulated reflectance is then demodulated using a lock-in amplifier. The presented sensor provides sensitivities of index of refraction about 4 × 10-8 RIU together with a 4 orders of magnitude dynamic range. This method demonstrates a sensitive detection scheme which could be used for label-free detection. © 2011 Elsevier B.V. All rights reserved.
      Keywords
      Surface plasmon resonance sensor
      Phase sensitive detection
      Lab-on-a-chip systems
      Microfluidic devices
      Optical sensors
      Permalink
      http://hdl.handle.net/11693/21655
      Published Version (Please cite this version)
      http://dx.doi.org/10.1016/j.snb.2011.08.046
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