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dc.contributor.authorKucukoglu, K.en_US
dc.contributor.authorMete, E.en_US
dc.contributor.authorCetin-Atalay, R.en_US
dc.contributor.authorGul H.I.en_US
dc.date.accessioned2016-02-08T09:46:07Z
dc.date.available2016-02-08T09:46:07Z
dc.date.issued2015en_US
dc.identifier.issn14756366
dc.identifier.urihttp://hdl.handle.net/11693/21425
dc.description.abstractSome 4-piperidinol derivatives were synthesized and their cytotoxicity was tested against human hepatoma (Huh7) and breast cancer (T47D) cells. Aryl part was changed as phenyl in 2a, 4-methylphenyl in 2b, 4-methoxyphenyl in 2c, 4-chlorophenyl in 2d, 4-fluorophenyl in 2e, 4-bromophenyl in 2f, 4-nitrophenyl in 2g and 2-thienyl in 3. Compounds were synthesized and reported for the first time by this study except 2a and 2d. Chemical structures were confirmed by 1H NMR, 13C NMR, IR, MS and elemental analyses. Compounds 2a (3.1 times), 2c (3.8 times), 2f (4.6 times), 2g (1.3 times) and 3 (3.2 times) had 1.3-4.6 times higher cytotoxic potency than the reference compound 5-FU against Huh7 cell line while all the compounds synthesized had shown lower activities against T47D cell line than 5-FU. In the light of these results, compounds 2a, 2c, 2f, 2g and 3 may serve as model compounds for further studies. © 2014 Informa UK Ltd.en_US
dc.language.isoEnglishen_US
dc.source.titleJournal of Enzyme Inhibition and Medicinal Chemistryen_US
dc.relation.isversionofhttp://dx.doi.org/10.3109/14756366.2014.951350en_US
dc.subjectCytotoxicityen_US
dc.subjectHuh7 cellsen_US
dc.subjectisopropylamineen_US
dc.subjectMannich basesen_US
dc.subjectT47D cellsen_US
dc.subject2 thienylen_US
dc.subject3 aroyl 4 aryl 1 isopropylamino 4 piperidinol derivativeen_US
dc.subject4 bromophenylen_US
dc.subject4 chlorophenylen_US
dc.subject4 fluorophenylen_US
dc.subject4 methoxyphenylen_US
dc.subject4 methylphenylen_US
dc.subject4 nitrophenylen_US
dc.subjectantineoplastic agenten_US
dc.subjectfluorouracilen_US
dc.subjectunclassified drugen_US
dc.subjectantineoplastic activityen_US
dc.subjectArticleen_US
dc.subjectbreast cancer cell lineen_US
dc.subjectcarbon nuclear magnetic resonanceen_US
dc.subjectcytotoxicityen_US
dc.subjectdrug synthesisen_US
dc.subjecthumanen_US
dc.subjecthuman cellen_US
dc.subjectinfrared spectroscopyen_US
dc.subjectliver cancer cell lineen_US
dc.subjectmass spectrometryen_US
dc.subjectpriority journalen_US
dc.subjectproton nuclear magnetic resonanceen_US
dc.titleSynthesis of 3-aroyl-4-aryl-1-isopropylamino-4-piperidinols and evaluation of the cytotoxicities of the compounds against human hepatoma and breast cancer cell linesen_US
dc.typeArticleen_US
dc.departmentDepartment of Molecular Biology and Geneticsen_US
dc.citation.spage564en_US
dc.citation.epage568en_US
dc.citation.volumeNumber30en_US
dc.citation.issueNumber4en_US
dc.identifier.doi10.3109/14756366.2014.951350en_US
dc.publisherTaylor and Francis Ltden_US


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