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      • Department of Molecular Biology and Genetics
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      Behavioural analyses of quinine processing in choice, feeding and learning of larval drosophila

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      Author
      El-Keredy, A.
      Schleyer, M.
      König, C.
      Ekim, A.
      Gerber, B.
      Date
      2012
      Source Title
      PLoS ONE
      Print ISSN
      19326203
      Volume
      7
      Issue
      7
      Language
      English
      Type
      Article
      Item Usage Stats
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      95
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      Abstract
      Gustatory stimuli can support both immediate reflexive behaviour, such as choice and feeding, and can drive internal reinforcement in associative learning. For larval Drosophila, we here provide a first systematic behavioural analysis of these functions with respect to quinine as a study case of a substance which humans report as "tasting bitter". We describe the dose-effect functions for these different kinds of behaviour and find that a half-maximal effect of quinine to suppress feeding needs substantially higher quinine concentrations (2.0 mM) than is the case for internal reinforcement (0.6 mM). Interestingly, in previous studies (Niewalda et al. 2008, Schipanski et al 2008) we had found the reverse for sodium chloride and fructose/sucrose, such that dose-effect functions for those tastants were shifted towards lower concentrations for feeding as compared to reinforcement, arguing that the differences in dose-effect function between these behaviours do not reflect artefacts of the types of assay used. The current results regarding quinine thus provide a starting point to investigate how the gustatory system is organized on the cellular and/or molecular level to result in different behavioural tuning curves towards a bitter tastant. © 2012 El-Keredy et al.
      Keywords
      quinine
      animal experiment
      article
      controlled study
      decision making
      Drosophila
      feeding behavior
      gustatory system
      larva
      learning
      nonhuman
      reinforcement
      taste
      Animals
      Behavior, Animal
      Choice Behavior
      Dose-Response Relationship, Drug
      Drosophila
      Larva
      Quinine
      Reinforcement (Psychology)
      Sucrose
      Taste
      Permalink
      http://hdl.handle.net/11693/21398
      Published Version (Please cite this version)
      http://dx.doi.org/10.1371/journal.pone.0040525
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