Numerical analysis of mixing performance in sinusoidal microchannels based on particle motion in droplets
Please cite this item using this persistent URLhttp://hdl.handle.net/11693/21236
Microfluidics and Nanofluidics
- Research Paper 
This numerical study was conducted to analyze and understand the parameters that affect the mixing performance of droplet-based flow in sinusoidal microfluidic channels. Finite element analysis was used for modeling fluid flow and droplet formation inside the microchannels via tracking interface between the two heterogeneous fluids along with multiple particle trajectories inside a droplet. The solutions of multiphase fluid flow and particle trajectories were coupled with each other so that drag on every single particle changed in every time step. To solve fluid motion in multiphase flow, level set method was used. Parametric study was repeated for different channel dimensions and different sinusoidal channel profiles. These results were compared with mixing in droplets inside a straight microchannel. Additionally, tracking of multiple particles inside a droplet was performed to simulate the circulating flow profile inside the droplets. Based on the calculation of the dispersion length, particle trajectories, and velocities inside droplets, it is concluded that having smaller channel geometries increases the mixing performance inside the droplet. This also shows that droplet-based fluid flow in microchannels is very suitable for performing chemical reactions inside droplets as it will occur faster. Moreover, narrower and sinusoidal microchannels showed better dispersion length difference compared to straight and wider microchannels. © 2015, Springer-Verlag Berlin Heidelberg.
Showing items related by title, author, creator and subject.
Marçalı, Merve (Bilkent University, 2015-10)Agglutination reactions have been carried out for several applications such as assessment of bacterial infection, blood typing or detecting non-infectious diseases. To observe agglutination reactions, several approaches ...
Kubra Isgor P.; Marcali, M.; Keser, M.; Elbuken, C. (Elsevier, 2015)Microfluidic capacitive sensors have been used for detection of droplets, however they have been lacking the sensitivity required for detecting the content of droplets. In this study, we developed a scalable, portable, ...
Özkazanç G.; Erdem E.Y. (Chemical and Biological Microsystems Society, 2016)We introduce capillary origami as a new method to print nanoparticles on curved, three dimensional polymer surfaces. When a liquid droplet containing nanoparticles is placed on a thin PDMS (polydimethylsiloxane) membrane, ...