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dc.contributor.authorLeong, S. C.en_US
dc.contributor.authorKartha, S. -S.en_US
dc.contributor.authorKathan, C.en_US
dc.contributor.authorSharp, J.en_US
dc.contributor.authorMortimore, S.en_US
dc.date.accessioned2016-02-08T09:43:14Z
dc.date.available2016-02-08T09:43:14Z
dc.date.issued2012en_US
dc.identifier.issn1879-7296
dc.identifier.urihttp://hdl.handle.net/11693/21218
dc.description.abstractObjectives: To evaluate the clinical outcomes of total laryngectomy (TL), complications and factors affecting survival. Design: Retrospective review of hospital electronic database for head and neck squamous cell carcinoma (SCCa). Setting: Large district general hospital in England, United Kingdom. Participants: Patients who had TL between January 1994 and January 2008. Main outcome measures: 5-year disease specific survival (DSS) and disease-free survival (DFS). Results and conclusions: Seventy-one patients were reviewed, of whom 38 (54%) had laryngeal SCCa and 33 (46%) hypopharyngeal SCCa. The overall mean survival period following TL was 42.4 months. The 5-year DSS and DFS was better for laryngeal SCCa compared to hypopharyngeal SCCa, although not statistically significant (P = 0.090, P = 0.54 respectively). Patients treated for laryngeal SCCa had a mean survival period of 47.5 months compared to 36.5 months for hypopharyngeal disease. Those who had laryngeal recurrence after primary radiotherapy (RT) demonstrated statistically better survival probability than those who had hypopharyngeal recurrence (P = 0.011). Patients without cervical lymphadenopathy had statistically better survival (P = 0.049). The most common early complication was related to the cardiorespiratory system. One fatal complication of erosion of the brachiocephalic artery due to the laryngectomy tube was noted. The most common late complication was neopharyngeal stenosis. The commonest cause of death was due to locoregional recurrence, followed by medical co-morbidities. Patients referred to specialised head and neck clinic had a better survival probability than those referred to a general ENT clinic (P = 0.37). While there is increasing tendency towards laryngeal conservation, total laryngectomy remains a robust treatment option in selected patients. © 2012 Elsevier Masson SAS.en_US
dc.language.isoEnglishen_US
dc.source.titleEuropean Annals of Otorhinolaryngology, Head and Neck Diseasesen_US
dc.relation.isversionofhttps://doi.org/10.1016/j.anorl.2011.10.012en_US
dc.subjectCanceren_US
dc.subjectHypopharynxen_US
dc.subjectLaryngectomyen_US
dc.subjectLarynxen_US
dc.subjectOutcomeen_US
dc.subjectBrachiocephalic artery erosionen_US
dc.subjectCancer radiotherapyen_US
dc.subjectCancer recurrenceen_US
dc.subjectCancer surgeryen_US
dc.subjectCancer survivalen_US
dc.subjectCervical lymphadenopathyen_US
dc.subjectDeep vein thrombosisen_US
dc.subjectDisease free survivalen_US
dc.subjectDisease specific survivalen_US
dc.subjectErosionen_US
dc.subjectEsophagus stenosisen_US
dc.subjectFemaleen_US
dc.subjectHead and neck squamous cell carcinomaen_US
dc.subjectHeart arrhythmiaen_US
dc.subjectHumanen_US
dc.subjectHypocalcemiaen_US
dc.subjectHypopharynx carcinomaen_US
dc.subjectHypothyroidismen_US
dc.subjectJejunal anastomotic stenosisen_US
dc.subjectLaryngectomyen_US
dc.subjectLarynx carcinomaen_US
dc.subjectMajor clinical studyen_US
dc.subjectMaleen_US
dc.subjectNeck neuromaen_US
dc.subjectNeopharyngeal stenosisen_US
dc.subjectPharyngeal leaken_US
dc.subjectPharyngo cutaneous fistulaen_US
dc.subjectPneumoniaen_US
dc.subjectPostoperative complicationen_US
dc.titleOutcomes following total laryngectomy for squamous cell carcinoma: one centre experienceen_US
dc.typeArticleen_US
dc.departmentDepartment of Economicsen_US
dc.citation.spage302en_US
dc.citation.epage307en_US
dc.citation.volumeNumber129en_US
dc.citation.issueNumber6en_US
dc.identifier.doi10.1016/j.anorl.2011.10.012en_US
dc.publisherElsevier Massonen_US


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