Cytotoxic activities of some novel benzhydrylpiperazine derivatives
Author
Gurdal, E. E.
Yarim, M.
Durmaz, I.
Cetin Atalay, R.
Date
2013Source Title
Drug Research
Print ISSN
2194-9379
Publisher
Georg Thieme Verlag
Volume
63
Issue
3
Pages
121 - 128
Language
English
Type
ArticleItem Usage Stats
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Show full item recordAbstract
This study presents the synthesis of nineteen 1-(substitutedbenzoyl)-4- benzhydrylpiperazine and 1-[(substitutedphenyl)sulfonyl]-4-benzhydrylpiperazine derivatives. In vitro cytotoxic activities of the compounds were screened against hepatocellular (HUH-7), breast (MCF-7) and colorectal (HCT-116) cancer cell lines by sulphorhodamine B assay. Among the test compounds, benzamide derivatives had high cytotoxic activity whereas sulfonamide derivatives showed variable 50% growth inhibition (GI50). © Georg Thieme Verlag KG Stuttgart · New York.
Keywords
BenzhydrylpiperazineBenzoyl chloride
Cytotoxicity
Sulfonyl chloride
Sulphorhodamine B
antineoplastic agent