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      • Department of Molecular Biology and Genetics
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      Cytotoxic activities of some novel benzhydrylpiperazine derivatives

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      Author
      Gurdal, E. E.
      Yarim, M.
      Durmaz, I.
      Cetin Atalay, R.
      Date
      2013
      Source Title
      Drug Research
      Print ISSN
      2194-9379
      Publisher
      Georg Thieme Verlag
      Volume
      63
      Issue
      3
      Pages
      121 - 128
      Language
      English
      Type
      Article
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      Abstract
      This study presents the synthesis of nineteen 1-(substitutedbenzoyl)-4- benzhydrylpiperazine and 1-[(substitutedphenyl)sulfonyl]-4-benzhydrylpiperazine derivatives. In vitro cytotoxic activities of the compounds were screened against hepatocellular (HUH-7), breast (MCF-7) and colorectal (HCT-116) cancer cell lines by sulphorhodamine B assay. Among the test compounds, benzamide derivatives had high cytotoxic activity whereas sulfonamide derivatives showed variable 50% growth inhibition (GI50). © Georg Thieme Verlag KG Stuttgart · New York.
      Keywords
      Benzhydrylpiperazine
      Benzoyl chloride
      Cytotoxicity
      Sulfonyl chloride
      Sulphorhodamine B
      antineoplastic agent
      Permalink
      http://hdl.handle.net/11693/21150
      Published Version (Please cite this version)
      http://dx.doi.org/10.1055/s-0032-1333275
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