Great ape genetic diversity and population history
Please cite this item using this persistent URLhttp://hdl.handle.net/11693/20899
Most great ape genetic variation remains uncharacterized; however, its study is critical for understanding population history, recombination, selection and susceptibility to disease. Here we sequence to high coverage a total of 79 wild- and captive-born individuals representing all six great ape species and seven subspecies and report 88.8 million single nucleotide polymorphisms. Our analysis provides support for genetically distinct populations within each species, signals of gene flow, and the split of common chimpanzees into two distinct groups: Nigeria-Cameroon/western and central/eastern populations. We find extensive inbreeding in almost all wild populations, with eastern gorillas being the most extreme. Inferred effective population sizes have varied radically over time in different lineages and this appears to have a profound effect on the genetic diversity at, or close to, genes in almost all species. We discover and assign 1,982 loss-of-function variants throughout the human and great ape lineages, determining that the rate of gene loss has not been different in the human branch compared to other internal branches in the great ape phylogeny. This comprehensive catalogue of great ape genome diversity provides a framework for understanding evolution and a resource for more effective management of wild and captive great ape populations. © 2013 Macmillan Publishers Limited. All rights reserved.
- Research Paper 
Showing items related by title, author, creator and subject.
Knappskog, S.; Gansmo L.B.; Dibirova, K.; Metspalu, A.; Cybulski, C.; Peterlongo P.; Aaltonen L.; Vatten L.; Romundstad P.; Hveem, K.; Devilee P.; Evans G.D.; Lin, D.; Van Camp G.V.; Manolopoulos V.G.; Osorio, A.; Milani L.; Ozcelik, T.; Zalloua P.; Mouzaya F.; Bliznetz, E.; Balanovska, E.; Pocheshkova, E.; Kucinskas V.; Atramentova L.; Nymadawa P.; Titov, K.; Lavryashina, M.; Yusupov, Y.; Bogdanova, N.; Koshel, S.; Zamora J.; Wedge, D.C.; Charlesworth, D.; Dörk, T.; Balanovsky O.; Lønning P.E. (Impact Journals LLC, 2014)The MDM2 promoter SNP285C is located on the SNP309G allele. While SNP309G enhances Sp1 transcription factor binding and MDM2 transcription, SNP285C antagonizes Sp1 binding and reduces the risk of breast-, ovary- and ...
Multi-population parallel genetic algorithm using a new genetic representation for the euclidean traveling salesman problem Kapanoglu, M.; Koç I.O.; Kara I.; Selim Aktürk, M. (2005)This paper introduces a multi-population genetic algorithm (M-PPGA) using a new genetic representation, the kth-nearest neighbor representation, for Euclidean Traveling Salesman Problems. The proposed M-PPGA runs M greedy ...
Polymorphisms of glutathione S-transferase genes (GSTM1, GSTP1 and GSTT1) and bladder cancer susceptibility in the Turkish population Törüner G.A.; Akyerli, C.; Uçar, A.; AkI, T.; Atsu, N.; Özen H.; Tez, M.; Çetinkaya, M.; Özçelik, T. (2001)We investigated the effect of the GSTM1 and GSTT1 null genotypes, and GSTP1 313 A/G polymorphism on bladder cancer susceptibility in a case control study of 121 bladder cancer patients, and 121 age- and sex-matched controls ...