Semi-automatic segmentation of subcutaneous tumours from micro-computed tomography images
Please cite this item using this persistent URLhttp://hdl.handle.net/11693/20713
Physics in Medicine and Biology
- Research Paper 
Institute of Physics Publishing
This paper outlines the first attempt to segment the boundary of preclinical subcutaneous tumours, which are frequently used in cancer research, from micro-computed tomography (microCT) image data. MicroCT images provide low tissue contrast, and the tumour-to-muscle interface is hard to determine, however faint features exist which enable the boundary to be located. These are used as the basis of our semi-automatic segmentation algorithm. Local phase feature detection is used to highlight the faint boundary features, and a level set-based active contour is used to generate smooth contours that fit the sparse boundary features. The algorithm is validated against manually drawn contours and micro-positron emission tomography (microPET) images. When compared against manual expert segmentations, it was consistently able to segment at least 70% of the tumour region (n = 39) in both easy and difficult cases, and over a broad range of tumour volumes. When compared against tumour microPET data, it was able to capture over 80% of the functional microPET volume. Based on these results, we demonstrate the feasibility of subcutaneous tumour segmentation from microCT image data without the assistance of exogenous contrast agents. Our approach is a proof-of-concept that can be used as the foundation for further research, and to facilitate this, the code is open-source and available from www.setuvo.com. © 2013 Institute of Physics and Engineering in Medicine.
Showing items related by title, author, creator and subject.
Hafalir F.S.; Oran O.F.; Gurler, N.; Ider, Y.Z. (Institute of Electrical and Electronics Engineers Inc., 2014)Images of electrical conductivity and permittivity of tissues may be used for diagnostic purposes as well as for estimating local specific absorption rate distributions. Magnetic resonance electrical properties tomography ...
Ider, Y.Z.; Onart, S.; Lionheart W.R.B. (2003)Magnetic resonance-electrical impedance tomography (MR-EIT) was first proposed in 1992. Since then various reconstruction algorithms have been suggested and applied. These algorithms use peripheral voltage measurements and ...
Özparlak L.; Ider, Y.Z. (2005)Magnetic resonance-electrical impedance tomography (MR-EIT) is a conductivity imaging method based on injecting currents into the object. In this study, a new MR-EIT method, whereby currents are induced inside the object ...