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dc.contributor.advisorDayanık, Savaş
dc.contributor.authorÇuhacı, Z Gülce
dc.date.accessioned2016-01-08T18:26:44Z
dc.date.available2016-01-08T18:26:44Z
dc.date.issued2013
dc.identifier.urihttp://hdl.handle.net/11693/15920
dc.descriptionAnkara : The Department of Industrial Engineering and the Graduate School of Engineering and Science of Bilkent University, 2013.en_US
dc.descriptionThesis (Master's) -- Bilkent University, 2013.en_US
dc.descriptionIncludes bibliographical references leaves 65-67.en_US
dc.description.abstractNanomedicine techniques are quite promising in terms of treatment and detection of cancerous cells. Targeted drug delivery plays an important role in this field of cancer nanotechnology. A lot of studies have been conducted so far concerning nanoparticle (NP)-cell interaction. Most of them fail to propose a mathematical model for a quantitative prediction of cellular uptake rate with measurable accuracy. In this thesis, we investigate cell-NP interactions and propose statistical models to predict cellular uptake rate. Size, surface charge, chemical structure (type), concentration of NPs and incubation time are known to affect the cellular uptake rate. Generalized linear models are employed to explain the change in uptake rate with the consideration of those effects and their interactions. The data set was obtained from in-vitro NP-healthy cell experiments conducted by the Nanomedicine & Advanced Technologies Research Center in Turkey. Statistical models predicting cellular uptake rate are proposed for sphere-shaped Silica, polymethyl methacrylate (PMMA), and polylactic acid (PLA) NPs.en_US
dc.description.statementofresponsibilityÇuhacı, Z Gülceen_US
dc.format.extentviii, 88 leaves, tables, graphsen_US
dc.language.isoEnglishen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectNanomedicineen_US
dc.subjectnanoparticle-cell interactionen_US
dc.subjectgeneralized linear modelsen_US
dc.subjectlogistic regressionen_US
dc.subjectsplinesen_US
dc.subject.lccQT36.5 .C84 2013en_US
dc.subject.lcshNanomedicine.en_US
dc.subject.lcshNanoparticles.en_US
dc.subject.lcshDrug delivery systems.en_US
dc.titleGeneralized linear models for in-vitro nanoparticle-cell interactionsen_US
dc.typeThesisen_US
dc.departmentDepartment of Industrial Engineeringen_US
dc.publisherBilkent Universityen_US
dc.description.degreeM.S.en_US


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