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      • Theses - Department of Molecular Biology and Genetics
      • Dept. of Molecular Biology and Genetics - Master's degree
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      •   BUIR Home
      • University Library
      • Bilkent Theses
      • Theses - Department of Molecular Biology and Genetics
      • Dept. of Molecular Biology and Genetics - Master's degree
      • View Item
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      Investigation of the effects of nicotine and levamisole on SW620 colon adenocarcinoma cells using a customized r-routine for automated microarray analysis

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      Author
      Üçal, Muammer
      Advisor
      Konu, Özlen
      Date
      2010
      Publisher
      Bilkent University
      Language
      English
      Type
      Thesis
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      Abstract
      Nicotine, the addictive component of tobacco, shows proliferative and antiapoptotic activity in cancer cells. Levamisole, an antihelmintic, on the other hand, has been tested as an additive chemotherapeutic agent and in treatment of nephrotic syndrome. Nicotine and levamisole are both agonists of nicotinic acetylcholine receptors; effects of these two agents have not been studied in colon cancer transcriptome. In this study, nicotine and levamisole exposed SW620 colon cancer cells, at a dose of 1 μM for 7 days, were studied with respect to changes in expression using microarrays. For data analysis, a custom R-routine which makes extensive use of open source R-BioConductor Project and associated packages has been written; and it is composed of three modules: QualCont module performs quality controls supported with several visual
      Keywords
      nicotine
      levamisole
      SW620
      colon cancer
      custom R routine
      automated microarray analysis
      Permalink
      http://hdl.handle.net/11693/15377
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      • Dept. of Molecular Biology and Genetics - Master's degree 135
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