Browsing Dept. of Molecular Biology and Genetics - Ph.D. / Sc.D. by Title
Now showing items 44-63 of 71
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Metastasis suppressor genes and proteins in non-melanoma skin cancers
(Bilkent University, 2014-09)Skin cancers are the most common cancer in human population. They are practically divided into two major group; melanoma and non-melanoma skin cancer (NMSC). NMSC often refers to two common neoplasms; cutaneous squamous ... -
Molecular mechanisms of senescence response to transforming growth factor-beta in liver cancer
(Bilkent University, 2010)Hepatocellular carcinoma (HCC) is the fifth most common cancer in the world. HCC is associated with several etiological factors including infections with hepatitis B and C viruses, heavy alcohol consumption and chronic ... -
NAPO as a novel apoptosis marker
(Bilkent University, 2002) -
Novel monoclonal antibodies targeting conformational ERBB2 epitopes
(Bilkent University, 2012)ERBB2 is a tyrosine kinase receptor which can act as homodimers or heterodimers with other members of the ERBB family. Nearly 30% of breast cancers overexpress ERBB2, which can be effectively targeted by anti-ERBB2 monoclonal ... -
A novel role for 5-hmC in the regulation of cancer testis gene expression in cancer and mesenchymal to epithelial transition
(Bilkent University, 2014-12)Cancer/testis (CT) genes show highly restricted expression among normal tissues, limited to germ cells in the testis and ovary, and to trophoblast cells, , but are frequently expressed in various cancers. Other than a ... -
p53 mutations as a source of aberrant Beta-catenin accumulation in cancer cells
(Bilkent University, 2002)β-catenin is involved in both cell-cell interactions and wnt pathway-dependent cell fate determination through its interactions with E-cadherin and TCF/LEF transcription factors, respectively. Cytoplasmic/nuclear levels ... -
Prediction of prognosis and chemosensitivity in breast cancer
(Bilkent University, 2020-09)Breast cancer (BC) is responsible for the highest mortality and morbidity out of all the cancers in women which is primarily due to both inter and intra-tumoral molecular heterogeneity. This heterogeneity arises from ... -
Prediction of prognosis and chemosensitivity in gastrointestinal cancers
(Bilkent University, 2018-01)Colon and gastric cancers are the third and fifth cancer types with the poorest survival. Surgery is considered the primary treatment option, which can be curative. However the decision as to whether chemotherapy ... -
Prevention of fatty acid-induced inflammasome activation by a bioactive lipokine
(Bilkent University, 2014) -
Quadrupedal gait in humans : identification and partial characterization of a novel gene WD repeat domain 81 (WDR81)
(Bilkent University, 2011)Identi cation of disease genes responsible for cerebellar phenotypes provides mechanistic insights into the development of cerebellum. Neural pathways involved in bipedal gait in humans is not completely understood. ... -
Reactivation of telomerase reverse transcriptase gene in liver cancer
(Bilkent University, 2014-09)Hepatocellular Carcinoma (HCC) is one of the major causes of cancer related deaths worldwide and its incidence has been increasing drastically, especially in western countries. HCC has a heterogeneous molecular and ... -
Regulation of human monocyte differentiation into m1- and m2-like macrophages
(Bilkent University, 2016-05)Myeloid-derived suppressor cells (MDSC) play a key role in down-regulating activated T and NK cells. MDSC are emerging as targets for cancer immunotherapy since they protect tumor cells from immune elimination. We ... -
Role of dietary ethiological factors in the molecular pathogenesis of liver cancer
(Bilkent University, 2011)Hepatocellular carcinoma is ranked third foremost cause of cancer deaths. Dietary factors play a crucial role in the molecular pathogenesis of liver cancer. Oxidative stress is usually coupled with the malignancy and ... -
Role of estrogen on the maintenance and homing capacity of bone marrow derived rat mesenchymal stem cells
(Bilkent University, 2011)Mesenchymal Stem Cells (MSCs) can self renew and differentiate into different cell types like, adipocytes, osteoblasts, chondrocytes, neurons, hepatocytes and endothelial cells. Their ability to differentiate into wide ... -
Role of histone variant H3.3 in transcription and mitotic progression
(Bilkent University, 2017-05)Chromatin structure needs to be dynamic and flexible in order for the eukaryotic cellular processes to function correctly. Incorporation of histone variants into chromatin serves to increase epigenetic plasticity by ... -
The role of IRE1 in metaflammation and atherosclerosis
(Bilkent University, 2017-06)Chronic metabolic overloading of anabolic and catabolic organelles such as the endoplasmic reticulum (ER) and mitochondria is a major cause of inflammation in obesity. ER serves as a critical metabolic center for protein, ... -
The role of lipid-induced integrated stress response in metaflammation and atherosclerosis
(Bilkent University, 2019-07)Chronic inflammation resulting from metabolic overloading of organelles (such as the endoplasmic reticulum (ER) and mitochondria that control cellular homeostasis) is a major cause of metabolic disorders including diabetes, ... -
Roles of senescence escape and epigenetic modifications in liver cancer
(Bilkent University, 2013)Development of hepatocellular carcinoma (HCC) is a multi-step progressive process in which a healthy liver transforms into cancerous tissue. Senescence is a permanent proliferation arrest in response to cell stress such ... -
Senescence and immortality genes as markers of hepatocellular carcinogenesis
(Bilkent University, 2009)Cellular senescence is a tumor-suppression mechanism, and immortalization facilitates neoplastic transformation. Both mechanisms may be highly relevant to hepatocellular carcinoma (HCC) development. We worked on two major ... -
Skewed x-chromosome inactivation in juvenile idiopathic arthritis and rheumatoid arthritis
(Bilkent University, 2012)There is a female predominance in most of the autoimmune diseases, and it is thought to play an important role in identifying the etiological factors. Sex hormones, microchimerism and environmental factors are thought ...
