Browsing Dept. of Molecular Biology and Genetics - Ph.D. / Sc.D. by Title
Now showing items 25-44 of 71
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Genetic and epigenetic analysis of immortal and senescence arrested liver cancer cells
(Bilkent University, 2009)Genetic and epigenetic aspects of cellular senescence and immortality in hepatocellular carcinoma (HCC) are poorly elucidated. The aim of our thesis was to characterize senescence and immortality gene network (SIGN) ... -
Genetic and epigenetic effect of estrogen on mesenchymal stem cell maintenance and differentiation
(Bilkent University, 2013)Mesenchymal stem cells (MSCs) have the potential to differentiate into multiple cell types and immune privileged characteristics. These features make MSCs a hope in tissue engineering and cell based treatment ... -
Genetic and epigenetic evaluation of the candidate genes in human hepatocellular carcinomas
(Bilkent University, 2010)Hepatocellular carcinoma (HCC) is the fifth most-common cancer and the third most common cause of cancer related mortality worldwide. HCC is also the most common type of liver cancer. Hepatocarcinogenesis is a multistep ... -
Genetic and epigenetic targets in liver cancer
(Bilkent University, 2010)Hepatocellular carcinoma (HCC) kills nearly 600.000 people each year and the only effective therapy for this cancer is liver transplantation or tumor ablation only when the tumor is small enough. These tumors are surprisingly ... -
Hepatocellular carcinoma viral etiology and molecular mechanisms
(Bilkent University, 2003)Hepatocellular carcinoma (HCC) is one of the most frequent carcinomas throughout the world, being responsible for more than 1 million deaths annually and has a strong association with several etiological factors including ... -
Heterogeneity of hepatocellular malignant phenotype
(Bilkent University, 2006)Hepatocellular carcinoma (HCC) is one of the most wide-spread carcinomas throughout the world - responsible for more than 600,000 deaths annually - and is strongly associated with several etiological factors; including ... -
Identification and utilization of autologous anti-tumor antibodies for the diagnosis and prognosis of cancer
(Bilkent University, 2015-12)Lung cancer is the leading cause of cancer related death worldwide. Current diagnostic methods have limited power and unable to extend patient life significantly. SCLC; the most aggressive subtype of lung cancer is an ... -
Identification of ATP8A2 gene mutation in a consaguineous family segregating cerebellar atrophy and quadrupedal gait
(Bilkent University, 2012)Cerebellar ataxia, mental retardation, and dysequilibrium syndrome is a rare and heterogeneous neurodevelopmental disorder characterized by cerebellar atrophy, dysarthric speech, and quadrupedal locomotion. Here, a ... -
Identification of genes induced by BRCA1 in breast cancer cells
(Bilkent University, 2002)Inherited mutations of the BRCA1 gene predispose to cancer of the breast, ovaries and other organs. The BRCA1 protein product is implicated in the maintenance of chromosomal integrity as BRCA1-deficient cells display ... -
Identification of novel genetic elements controlling transcriptional regulation of the human Na(formula)/I(formula) symporter (NIS) gene
(Bilkent University, 2006)The function of sodium iodide symporter (NIS) in mammary gland epithelial cells is essential for the accumulation of iodide in mother’s milk, which is the first source of iodide for the synthesis of thyroid hormones in ... -
Identification of putative protein kinase inhibitors acting on liver cancer cells
(Bilkent University, 2012)Hepatocellular carcinoma (HCC) as a, heterogeneous, multi-step, slowprogressing disease, has very limited treatment options due to its chemoresistant nature and late diagnosis. According to World Health Organization ... -
Identification of the role of the nuclear matrix protein C1D in DNA repair and recombination
(Bilkent University, 2002)The nuclear matrix protein C1D is an activator of the DNA dependent protein kinase (DNA-PK), which is essential for the repair of DNA double-strand breaks (DNA-DSBs). C1D is phosphorylated very efficiently by DNA-PK, and ... -
Identifying and targeting coding/non-coding molecular switches regulating drug resistance and metastasis in breast cancer
(Bilkent University, 2017-09)Breast cancer is the second most common cancer and the leading cause of cancer associated deaths in women worldwide. Despite the availability of large number and various types of therapy agents which are effective in ... -
Immunotherapeutic action of extracellular vesicles and effects of TLR signaling to immune dysfunction of SCI patients
(Bilkent University, 2017-03)The primary aim of this thesis is to extend the breadth of in vivo application of externally loaded exosomes as prophylactic or therapeutic carriers against disease treatment. Exosomes are secreted from all cells and ... -
Immunotherapeutic applications of nucleic acid based tlr agonists and antagonists
(Bilkent University, 2014)Recent evidence suggests that genetic material is not just the blueprint of life. Depending on the type of the source that genomic material is extracted or the type of motif that DNA harbors DNA could be immunostimulatory ... -
In silico identification of candidate MECP2 targets and quantitative analysis in rett syndrome
(Bilkent University, 2006)Rett syndrome (RTT) is an X-linked neuro-developmental disorder seen exclusively girls in the childhood. It is one of the most common causes of mental retardation with an incidence rate of 1/10,000-1/15,000. Mutations ... -
In vivo applications of liposomal vaccines encapsulating single or dual pathogenassociated molecular patterns
(Bilkent University, 2017-03)Nucleic acid-based pattern recognition receptor (PRR) agonists are promising adjuvants and immunotherapeutic agents. Combination of PRR ligands potentiates immune response by providing synergistic immune activity via ... -
Investigation of novel RNAi and nanoparticle approaches for their anti-proliferative and drug-sensitizing effects in breast cancer
(Bilkent University, 2017-08)Drug resistivity remains a major challenge in treating different cancer types. Among several strategies adapted to increase drug sensitivity in breast cancer cells, in the present thesis I studied an RNAi molecule targeting ... -
Metastasis suppressor genes and proteins in non-melanoma skin cancers
(Bilkent University, 2014-09)Skin cancers are the most common cancer in human population. They are practically divided into two major group; melanoma and non-melanoma skin cancer (NMSC). NMSC often refers to two common neoplasms; cutaneous squamous ...
