Dept. of Molecular Biology and Genetics - Ph.D. / Sc.D.
Recent Submissions
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Identification of actionable drug targets in triple-negative breast cancer
(Bilkent University, 2022-09)Triple-negative breast cancer (TNBC) is the most aggressive subtype of the breast cancer, representing 15-20% of all cases. Due to a lack of clinically available/approved targeted therapies, TNBC patients are still in ... -
The development of prophylactic and therapeutic vaccine using cell derived extracellular vesicles
(Bilkent University, 2022-08)The primary aim of this thesis is to extend the breadth of in vivo application of externally loaded cell-line derived and tumor derived exosomes as a prophylactic and therapeutic carrier against cancer treatment. Exosomes ... -
Investigating the targets and biological roles of IRE1’s two enzymatic activities
(Bilkent University, 2022-06)The unfolded protein response (UPR) is composed of complex and intricate series of highly regulated pathways geared to resolve the accumulation of misfolded proteins and to maintain cellular homeostasis. Endoplasmic reticulum ... -
Characterization of a novel IRE1 substrate pact and interacting miRNAS
(Bilkent University, 2022-06)The double-stranded RNA-dependent protein kinase activator A (PACT) anchors the RNAinduced silencing complex (RISC) to the endoplasmic reticulum (ER)’s membranous platform where RISC nucleation occurs and thus, PACT plays ... -
Identification of a novel substrate of IRE1 in lipotoxic stress response
(Bilkent University, 2022-02)Fragile X Mental Retardation protein (FMRP), widely known for its role in hereditary intellectual disability, is a ribonucleic acid (RNA)-binding protein (RBP) that controls translation of select messenger RNAs (mRNAs). ... -
The role of mediator complex in tamoxifen resistance of ER-positive breast cancer
(Bilkent University, 2022-01)Breast cancer is the most prevalent cancer type and the leading cause of cancer mortality among women worldwide. Estrogen receptor-positive (ER+) breast cancer is the most common clinical subtype with an incidence rate ... -
Characterization of the fine-scale genetic structure of the Turkish population
(Bilkent University, 2022-01)The construction of population-based genetic resources plays a pivotal role in the study of human biology and disease. In this study, the fine-scale genetic structure of the Turkish (TR) population was characterized using ... -
Characterization of functional and molecular properties of circulating extracellular vesicles of childhood idiopathic nephrotic syndrome patients
(Bilkent University, 2021-10)Nephrotic syndrome (NS) is one of the most common causes of glomerular disease in children and is characterized by the triad of proteinuria, hypoalbuminemia, and edema. The major molecular event in the pathogenesis of NS ... -
Multiomics approaches to overcome drug resistance in cancer
(Bilkent University, 2021-09)Chemotherapy resistance remains one of the major challenges in cancer treatment. Most of the studies on drug resistance have focused on genetic evolution of cancer cells; however, this focus has shifted to non-genetic and ... -
BO-264: Highly potent TACC3 inhibitor as a novel anticancer drug candidate
(Bilkent University, 2021-01)Breast cancer has been consistently ranked to be the most common cancer and the second leading cause of cancer-related death in women worldwide for many years. Despite better understanding of tumor biology and the availability ... -
Development of a specialized zebrafish xenotransplantation database and establishment of ALU-based tumor DNA quantification method in zebrafish: focus on models of overexpression and microenvironment
(Bilkent University, 2020-09)Successful xenotransplantation of human cancer cells into zebrafish host marked a new era in cancer research enabling high throughput in vivo screens. Zebrafish xenotransplantation literature continues to rapidly accumulate, ... -
Prediction of prognosis and chemosensitivity in breast cancer
(Bilkent University, 2020-09)Breast cancer (BC) is responsible for the highest mortality and morbidity out of all the cancers in women which is primarily due to both inter and intra-tumoral molecular heterogeneity. This heterogeneity arises from ... -
Elucidating immunomodulatory effects of telomeric repeat mimicking synthetic A151 oligodeoxynucleotide on immune cell transcriptome
(Bilkent University, 2019-09)Recent evidence revealed that DNA is beyond just the blueprint of life; it is also involved in immunomodulation. Unmethylated Cytosine-phosphate-Guanine (CpG) motifs of prokaryotic DNA stimulate immune response by ... -
The role of lipid-induced integrated stress response in metaflammation and atherosclerosis
(Bilkent University, 2019-07)Chronic inflammation resulting from metabolic overloading of organelles (such as the endoplasmic reticulum (ER) and mitochondria that control cellular homeostasis) is a major cause of metabolic disorders including diabetes, ... -
TLR agonists on autoimmunity, cancer and M1/M2 macrophage polarization
(Bilkent University, 2019-07)Macrophages play an important role in the initiation of immune responses and the maintenance of immune homeostasis. Alterations in their phenotype, function and activation state have been implicated in the pathogenesis ... -
Effects of Cholinergic Receptor Nicotinic Alpha 5 (CHRNA5) RNAi on apoptosis, DNA damage response, drug sensitivity, and HSA-MIR-495-3P overexpression in breast cancer
(Bilkent University, 2018-12)Cholinergic Receptor Nicotinic Alpha 5 (CHRNA5) is associated with nicotine addiction and it has an important role in the prognosis of lung cancer. Despite its important cellular functions, its role in breast cancer remains ... -
Effects of PI3K/AKT/MTOR and VEGFR pathway inhibitors on liver cancer stem cells and bioactivities of novel pyrazolic chalcone derivatives on liver cancer
(Bilkent University, 2017-12)Hepatocellular carcinoma (HCC) is one of the leading causes of cancer-related mortality, such that it the second most frequent cause of cancer death worldwide. Due to its heterogeneous composition and aggressive behavior, ... -
Prediction of prognosis and chemosensitivity in gastrointestinal cancers
(Bilkent University, 2017-12)Colon and gastric cancers are the third and fifth cancer types with the poorest survival. Surgery is considered the primary treatment option, which can be curative. However the decision as to whether chemotherapy ... -
Identifying and targeting coding/non-coding molecular switches regulating drug resistance and metastasis in breast cancer
(Bilkent University, 2017-09)Breast cancer is the second most common cancer and the leading cause of cancer associated deaths in women worldwide. Despite the availability of large number and various types of therapy agents which are effective in ... -
Development of novel tools for cancer diagnosis, prognosis and treatment using intra- or inter-species transcriptome metaanalysis
(Bilkent University, 2017-08)In the past decades, a considerable number of studies have performed meta-analysis on large data collections to prioritize sets of genes, pathways or types/categories of disease focusing on either differential expression, ...
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