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Functional analysis of transgelin in breast cancer
(Bilkent University, 2018-06)
Transgelin (TAGLN) is an actin-binding protein. It is highly expressed in fibroblasts and smooth muscle cells. In smooth muscle cells, it takes part in processes including motility and differentiation and also it has a ...
Investigating the role of the mediator complex in estrogen receptor alpha-mediated transcription
(Bilkent University, 2018-07)
Mediator is the most important coregulator in eukaryotic transcription. It conveys the signals received from transcriptional activators on enhancer sequences to transcription machinery on promoter regions. Although Mediator ...
Immunomodulatory effects of exosomes: promising candidates in immunotherapy
(Bilkent University, 2018-08)
Exosomes are type of extracellular vesicles secreted from almost all cell types and
carry numerous biological molecules such as nucleic acids, protein and lipids. They
mediate many cellular processes including cellular ...
Evaluation of TAGLN as a diagnostic marker in breast cancer
(Bilkent University, 2018-08)
Silecing of tumor suppressor genes via CpG hypermethylation in promoter regions
is one of the frequent events occurring in different types of cancers. These genes
have the potential as a diagnostic or a prognostic ...
Identification of the roles played by IKKε in hepatocellular and colorectal carcinogenesis
(Bilkent University, 2018-07)
Hepatocellular carcinomas (HCC) and colorectal carcinomas (CRC) are among the most common cancers worldwide with high mortality rates. While HCC affecting mostly underdeveloped countries, CRC is a disease that mainly occur ...
Identification of long non-coding RNAs overcoming tamoxifen resistance in estrogen receptor alpha positive breast cancer
(Bilkent University, 2017-09)
Most of the breast cancer incidences all over the world fall into Estrogen Receptor alpha
(ERα)-positive breast cancer subtype, which are treated with endocrine therapy. Tamoxifen, a
selective ER modulator drug, is the ...
Investigation of the role of cGAMP in differentiation of T lymphocytes
(Bilkent University, 2016-10)
STING is the pivotal mediator for the recognition of host and pathogenic cytosolic
dsDNA as well as cyclic di-nucleotides metabolites from microbes. STING can either
recognize DNA itself or sense the presence of cGAMP, ...
Regulation of mineralocorticoid receptor and its downstream targets by estrogen and aldosterone in breast cancer
(Bilkent University, 2016-11)
Many women suffer from breast cancer worldwide thus accurate diagnosis of this disease has become an important issue for treatment options and improved clinical outcomes. Members of steroid hormone receptors, are a subfamily ...
Elucidation of Sorafenib resistance mechanisms in hepatocellular carcinoma
(Bilkent University, 2018-07)
Hepatocellular Carcinoma (HCC) is the sixth most common type of cancer and the second leading cause of cancer-related deaths worldwide. Currently, Sorafenib is the only approved first-line treatment option for unresectable ...
Identification of general transcription Factor-Two-E and mediator complex interactions in the context of pre-initiation complex formation
(Bilkent University, 2018-06)
Transcription is a multistep process which requires the presence of many different proteins and protein complexes. The minimal protein components enabling transcription to happen are identified to execute the event in ...