p53 is a tumor suppressor gene which is mutated in about 50% of human cancers. The product of p53 gene encodes a sequence-specific transcription factor. The genes are transactivated by p53 code for proteins that are ...

Selenium (Se) plays an important role in eliminating the reactive oxygen species generated during oxidative stress. Se-containing selenocysteine is an essential amino acid required for the synthesis of many selenoproteins, ...

The hepatitis C virus (HCV) infection is an important cause of morbidity and mortality world wide. Infection with HCV becomes chronic in more than 80% of the cases and it accounts for 20%of all cases of acute hepatitis. ...

Breast cancer is known to be the most common cancer among women in the world. It is assumed that one in ten women will develop breast cancer till the age 80. Heredity is the major risk determinant in breast cancer. 30% of ...

Hepatocellular carcinoma (HCC) is the eighth most frequent cancer worldwide, iipidemiologically-studied risk factors include hepatitis B virus (greater than 80%), hepatitis C virus and aflatoxins. Molecular mechanisms of ...

Hepatitis C Virus is a major cause of acute and chronic hepatitis worldwide. 80-90% of Hepatitis C Virus infections become chronic and 75% of these cases lead to liver disease, including cirrhosis, liver failure and ...

DNA Double-strand breaks (DSBs) are generated as intermediate stnictures during V(D)J recombination, as a consequence of oxidative metabolism, or can be induced by exogenous factors such as gamma irradiation and radiomimetic ...

The aim of this vv^ork was to establish an experimental model to study human wild type and mutant p53 protein effects in yeast Saccharomyces cerevisiae cells. Wild type p53 was previously shown to be a DNA damage response ...

At least two classes of genes are involved directly or indirectly in the regulation of cell growth and differentiation. One group of these genes, known as tumor suppressor genes, is involved in cellular regulation by ...

HCC is a multistep genetic disease in which many genomic changes occur as a result of uncontrolled proliferation of hepatocytes. Molecular events leading to HCC is still unclear. Until now, neither an oncogene nor a tumor ...